C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ADAM metallopeptidase domain 17
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000151694 ADAM17 9606 - 2:9488486-9555792 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000310823 ADAM17-001 9488486-9555788 protein_coding
  ENST00000478059 ADAM17-002 9527501-9555774 retained_intron
  ENST00000497134 ADAM17-003 9521596-9555792 protein_coding
  ENST00000618923 ADAM17-201 9521598-9555792 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000310823ENST00000497134ENST00000618923
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000310823 14.242±0.00 8.481±0.00 0.623±0.00 3.175±2.08 6.607±0.00 2.929±2.09 2.439±1.41 3.668±0.00 1.883±0.23 8.670±1.22 2.781±1.90 6.401±0.72 8.428±1.54 7.970±1.61
ENST00000497134 N/A N/A N/A N/A N/A 2.032±0.00 N/A N/A 2.205±0.00 N/A N/A N/A N/A N/A
ENST00000618923 N/A N/A 1.285±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00057M CIL_00057M_0001 CGP 2:9423568-9496543
CIL_0007AU CIL_0007AU_0002 CGP 2:9473658-9555792
CIL_0001MI CIL_0001MI_0001 CGP 2:9488486-9631014

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IDA response to hypoxia
GO:0001934 IMP positive regulation of protein phosphorylation
GO:0002446 IC neutrophil mediated immunity
GO:0002467 ISS germinal center formation
GO:0002690 IC positive regulation of leukocyte chemotaxis
GO:0004222 IDA:IEA metalloendopeptidase activity
GO:0005112 IDA Notch binding
GO:0005138 IPI interleukin-6 receptor binding
GO:0005178 IPI integrin binding
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005886 TAS plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0005911 IDA cell-cell junction
GO:0005925 IDA focal adhesion
GO:0006508 IDA:IEA proteolysis
GO:0006509 IMP membrane protein ectodomain proteolysis
GO:0006915 TAS apoptotic process
GO:0007155 IDA cell adhesion
GO:0007173 IDA epidermal growth factor receptor signaling pathway
GO:0007219 IEA Notch signaling pathway
GO:0007220 IDA Notch receptor processing
GO:0008237 IMP metallopeptidase activity
GO:0008270 IEA zinc ion binding
GO:0008284 IMP positive regulation of cell proliferation
GO:0009986 IDA cell surface
GO:0010820 IMP positive regulation of T cell chemotaxis
GO:0015629 IDA actin cytoskeleton
GO:0016020 IDA membrane
GO:0016324 IDA apical plasma membrane
GO:0017124 IEA SH3 domain binding
GO:0022617 TAS extracellular matrix disassembly
GO:0030165 IPI PDZ domain binding
GO:0030183 ISS B cell differentiation
GO:0030198 TAS extracellular matrix organization
GO:0030307 IMP positive regulation of cell growth
GO:0030335 IMP positive regulation of cell migration
GO:0030511 ISS positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030512 IMP negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030574 TAS collagen catabolic process
GO:0031293 TAS membrane protein intracellular domain proteolysis
GO:0031659 IDA positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0032496 IDA response to lipopolysaccharide
GO:0032587 IDA ruffle membrane
GO:0032717 IMP negative regulation of interleukin-8 production
GO:0032722 IMP positive regulation of chemokine production
GO:0033025 ISS regulation of mast cell apoptotic process
GO:0033077 ISS T cell differentiation in thymus
GO:0033627 IDA cell adhesion mediated by integrin
GO:0035313 IEP wound healing, spreading of epidermal cells
GO:0035625 IMP epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0042493 ISS response to drug
GO:0045121 IDA membrane raft
GO:0045741 IMP positive regulation of epidermal growth factor-activated receptor activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048536 ISS spleen development
GO:0048870 ISS cell motility
GO:0051088 IDA PMA-inducible membrane protein ectodomain proteolysis
GO:0051272 ISS positive regulation of cellular component movement
GO:0055099 IDA response to high density lipoprotein particle
GO:0060397 TAS JAK-STAT cascade involved in growth hormone signaling pathway
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000043213 adam17a a disintegrin and metalloproteinase domain 17a protein_coding Danio_rerio
ENSDARG00000093093 adam17b a disintegrin and metallopeptidase domain 17b protein_coding Danio_rerio
ENSMUSG00000052593 Adam17 a disintegrin and metallopeptidase domain 17 protein_coding Mus_musculus

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