C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: angiopoietin 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000154188 ANGPT1 9606 - 8:107249482-107498055 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000297450 ANGPT1-003 107249493-107498055 protein_coding
  ENST00000517746 ANGPT1-001 107249482-107498010 protein_coding
  ENST00000518386 ANGPT1-007 107251527-107321989 processed_transcript
  ENST00000520033 ANGPT1-006 107346983-107494995 protein_coding
  ENST00000520052 ANGPT1-009 107251512-107336522 protein_coding
  ENST00000520734 ANGPT1-002 107251512-107336522 protein_coding
  ENST00000521950 ANGPT1-005 107283997-107321993 retained_intron
  ENST00000522400 ANGPT1-008 107284519-107295541 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000297450ENST00000517746ENST00000518386ENST00000520052ENST00000520734
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000297450 0.614±0.00 N/A N/A 0.448±0.36 N/A 0.472±0.00 0.188±0.00 N/A N/A N/A N/A 0.184±0.00 N/A N/A
ENST00000517746 1.452±0.00 0.538±0.00 0.999±0.00 0.278±0.00 6.704±3.89 1.155±0.00 0.854±0.28 1.734±0.00 2.351±0.00 9.725±0.69 0.399±0.06 0.684±0.41 0.566±0.16 1.173±1.07
ENST00000518386 N/A N/A N/A N/A N/A N/A N/A 0.956±0.00 0.080±0.00 N/A 4.104±0.00 0.286±0.00 1.710±0.00 0.911±0.00
ENST00000520052 N/A N/A N/A 0.289±0.00 N/A 1.256±0.00 0.957±0.00 N/A 1.747±0.00 6.155±0.00 N/A 0.789±0.00 0.374±0.00 N/A
ENST00000520734 N/A N/A 1.418±0.00 N/A 1.326±0.00 0.753±0.00 N/A N/A 2.057±0.00 N/A N/A 0.278±0.00 0.573±0.00 0.556±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004T0 CIL_0004T0_0002 CGP 8:106759483-107498055
CIL_000608 CIL_000608_0001 CGP 8:107249482-108083648

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0001701 IEA in utero embryonic development
GO:0001933 IEA negative regulation of protein phosphorylation
GO:0002040 IDA sprouting angiogenesis
GO:0002092 IDA positive regulation of receptor internalization
GO:0002740 IEA negative regulation of cytokine secretion involved in immune response
GO:0005102 IEA receptor binding
GO:0005576 TAS extracellular region
GO:0005615 IDA extracellular space
GO:0005886 IDA plasma membrane
GO:0005902 IDA microvillus
GO:0007162 IDA negative regulation of cell adhesion
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007171 IDA activation of transmembrane receptor protein tyrosine kinase activity
GO:0007596 TAS blood coagulation
GO:0010595 IDA positive regulation of endothelial cell migration
GO:0014068 IEA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014842 IDA regulation of satellite cell proliferation
GO:0030097 IEA hemopoiesis
GO:0030154 IEA cell differentiation
GO:0030210 IDA heparin biosynthetic process
GO:0030971 IEA:IPI receptor tyrosine kinase binding
GO:0031398 IDA positive regulation of protein ubiquitination
GO:0031589 IEA cell-substrate adhesion
GO:0032680 IEA regulation of tumor necrosis factor production
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0034394 IDA protein localization to cell surface
GO:0042308 IEA negative regulation of protein import into nucleus
GO:0043066 IDA negative regulation of apoptotic process
GO:0043116 IDA negative regulation of vascular permeability
GO:0043122 IEA regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043393 IEA regulation of protein binding
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0043536 IDA positive regulation of blood vessel endothelial cell migration
GO:0045121 IDA membrane raft
GO:0045785 IEA positive regulation of cell adhesion
GO:0048014 IEA:IDA Tie signaling pathway
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050900 TAS leukocyte migration
GO:0050918 IDA positive chemotaxis
GO:0051897 IDA positive regulation of protein kinase B signaling
GO:0070062 IDA extracellular vesicular exosome
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0072012 ISS glomerulus vasculature development
GO:2000352 IDA negative regulation of endothelial cell apoptotic process
GO:2000446 IEA regulation of macrophage migration inhibitory factor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000030364 angpt1 angiopoietin 1 protein_coding Danio_rerio
ENSMUSG00000022309 Angpt1 angiopoietin 1 protein_coding Mus_musculus

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