C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: angiopoietin 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022309 Angpt1 10090 - 15:42424727-42676977 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000022921 Angpt1-201 42424727-42676977 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000022921
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000022921 0.940±0.10 0.071±0.02 0.862±0.15 1.361±0.12 0.946±0.25 0.180±0.11 4.886±0.47 1.355±0.63 0.368±0.34 4.787±1.47 0.951±0.36 1.071±0.85 0.613±0.25 0.057±0.02

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004T0 CIL_0004T0_0003 CGP 15:41865293-42676977
CIL_000608 CIL_000608_0002 CGP 15:42424727-43170818

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IDA angiogenesis
GO:0001569 TAS patterning of blood vessels
GO:0001570 TAS vasculogenesis
GO:0001701 IGI in utero embryonic development
GO:0001933 IDA negative regulation of protein phosphorylation
GO:0002040 IEA sprouting angiogenesis
GO:0002092 IEA positive regulation of receptor internalization
GO:0002740 IDA negative regulation of cytokine secretion involved in immune response
GO:0003160 TAS endocardium morphogenesis
GO:0005102 IPI receptor binding
GO:0005172 TAS vascular endothelial growth factor receptor binding
GO:0005615 IEA extracellular space
GO:0005886 IEA plasma membrane
GO:0005902 IEA microvillus
GO:0007162 IEA negative regulation of cell adhesion
GO:0007169 IDA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007171 IEA activation of transmembrane receptor protein tyrosine kinase activity
GO:0007492 TAS endoderm development
GO:0010595 TAS positive regulation of endothelial cell migration
GO:0014068 IDA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014842 IEA regulation of satellite cell proliferation
GO:0030097 IDA hemopoiesis
GO:0030210 IEA heparin biosynthetic process
GO:0030949 TAS positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0030971 IEA receptor tyrosine kinase binding
GO:0031398 IEA positive regulation of protein ubiquitination
GO:0031589 IDA cell-substrate adhesion
GO:0032680 IDA regulation of tumor necrosis factor production
GO:0033138 IDA positive regulation of peptidyl-serine phosphorylation
GO:0034394 IEA protein localization to cell surface
GO:0042308 IDA negative regulation of protein import into nucleus
GO:0043066 IEA negative regulation of apoptotic process
GO:0043116 IDA negative regulation of vascular permeability
GO:0043122 IGI regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043393 IDA regulation of protein binding
GO:0043524 IDA negative regulation of neuron apoptotic process
GO:0043536 IEA positive regulation of blood vessel endothelial cell migration
GO:0045121 IEA membrane raft
GO:0045785 IDA positive regulation of cell adhesion
GO:0048014 TAS Tie signaling pathway
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 IEA positive chemotaxis
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0055008 TAS cardiac muscle tissue morphogenesis
GO:0060979 TAS vasculogenesis involved in coronary vascular morphogenesis
GO:0070062 IEA extracellular vesicular exosome
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0072012 IDA glomerulus vasculature development
GO:2000352 IEA negative regulation of endothelial cell apoptotic process
GO:2000446 IDA regulation of macrophage migration inhibitory factor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000030364 angpt1 angiopoietin 1 protein_coding Danio_rerio
ENSG00000154188 ANGPT1 angiopoietin 1 protein_coding Homo_sapiens

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