C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitochondrial calcium uniporter
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000156026 MCU 9606 + 10:72692131-72887694 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000357157 MCU-001 72692143-72887694 protein_coding
  ENST00000373053 MCU-002 72692131-72887694 protein_coding
  ENST00000483185 MCU-003 72859995-72868806 retained_intron
  ENST00000536019 MCU-201 72692619-72887692 protein_coding
  ENST00000603118 MCU-009 72868690-72884431 processed_transcript
  ENST00000603649 MCU-007 72692143-72834420 nonsense_mediated_decay
  ENST00000604152 MCU-008 72712304-72868812 protein_coding
  ENST00000604372 MCU-004 72692143-72871433 nonsense_mediated_decay
  ENST00000604679 MCU-005 72692143-72871545 nonsense_mediated_decay
  ENST00000605416 MCU-010 72868844-72887691 processed_transcript
  ENST00000605597 MCU-006 72692619-72887692 nonsense_mediated_decay
  ENST00000622066 MCU-202 72692619-72887692 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000373053ENST00000603118ENST00000604372ENST00000604679ENST00000605416ENST00000605597
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000373053 3.256±0.00 1.728±0.00 0.267±0.00 0.975±0.00 3.632±0.00 2.769±0.00 1.394±0.61 2.320±1.70 1.482±0.00 3.925±1.05 7.243±0.00 5.197±1.75 4.201±1.38 2.873±0.00
ENST00000603118 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.286±0.00
ENST00000604372 N/A N/A N/A N/A 6.511±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000604679 N/A N/A N/A N/A N/A 6.470±0.00 0.632±0.00 N/A 3.455±0.00 N/A 5.902±0.00 3.785±0.00 N/A N/A
ENST00000605416 0.898±0.00 2.295±0.00 1.344±0.00 1.954±0.00 2.176±0.00 3.346±0.00 1.247±0.00 1.493±1.25 0.794±0.00 4.051±0.00 1.815±0.00 3.525±2.24 1.899±0.54 1.877±1.22
ENST00000605597 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.865±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008QA CIL_0008QA_0001 VISTA 10:72591086-73192639

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005262 IDA calcium channel activity
GO:0005515 IPI protein binding
GO:0005739 IEA mitochondrion
GO:0005743 IDA mitochondrial inner membrane
GO:0006851 IMP mitochondrial calcium ion transport
GO:0015292 IDA uniporter activity
GO:0019722 IDA calcium-mediated signaling
GO:0031305 IDA integral component of mitochondrial inner membrane
GO:0032024 IMP positive regulation of insulin secretion
GO:0034704 ISS calcium channel complex
GO:0035786 IDA protein complex oligomerization
GO:0036444 IDA calcium ion transmembrane import into mitochondrion
GO:0042593 IMP glucose homeostasis
GO:0042802 IEA identical protein binding
GO:0051560 IEA mitochondrial calcium ion homeostasis
GO:0051561 IMP positive regulation of mitochondrial calcium ion concentration
GO:0055085 IEA transmembrane transport
GO:1990246 IDA uniplex complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000026804 mcu mitochondrial calcium uniporter protein_coding Danio_rerio
ENSMUSG00000009647 Mcu mitochondrial calcium uniporter protein_coding Mus_musculus

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