C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitochondrial calcium uniporter
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000009647 Mcu 10090 - 10:59446984-59616692 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000009791 Mcu-004 59448597-59458160 protein_coding
  ENSMUST00000020312 Mcu-001 59446984-59616692 protein_coding
  ENSMUST00000161168 Mcu-002 59602011-59616679 processed_transcript
  ENSMUST00000161435 Mcu-003 59532846-59616675 nonsense_mediated_decay
  ENSMUST00000162012 Mcu-005 59602775-59616655 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000009791ENSMUST00000020312
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000009791 N/A N/A N/A 2.583±0.00 N/A N/A N/A N/A N/A N/A N/A 1.980±0.00 N/A 5.407±0.86
ENSMUST00000020312 7.812±2.31 21.338±5.42 29.386±1.01 5.323±1.30 5.836±2.58 57.720±11.44 5.778±0.26 9.178±0.50 6.639±2.91 10.963±2.13 8.372±0.87 12.079±4.73 6.891±2.04 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008QA CIL_0008QA_0002 VISTA 10:59142760-59744333
CIL_0006SA CIL_0006SA_0002 CGP 10:59422958-59616692

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005262 ISS calcium channel activity
GO:0005515 IPI protein binding
GO:0005739 IDA mitochondrion
GO:0005743 ISS mitochondrial inner membrane
GO:0006851 IMP mitochondrial calcium ion transport
GO:0015292 IEA uniporter activity
GO:0019722 ISS calcium-mediated signaling
GO:0031305 ISS integral component of mitochondrial inner membrane
GO:0032024 ISS positive regulation of insulin secretion
GO:0034704 IDA calcium channel complex
GO:0035786 ISS protein complex oligomerization
GO:0036444 ISO calcium ion transmembrane import into mitochondrion
GO:0042593 ISS glucose homeostasis
GO:0042802 IPI identical protein binding
GO:0051560 IEA mitochondrial calcium ion homeostasis
GO:0051561 IMP positive regulation of mitochondrial calcium ion concentration
GO:0055085 IEA transmembrane transport
GO:1990246 ISS uniplex complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000026804 mcu mitochondrial calcium uniporter protein_coding Danio_rerio
ENSG00000156026 MCU mitochondrial calcium uniporter protein_coding Homo_sapiens

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