C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: mitochondrial calcium uniporter
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000373053 MCU-002 ENSG00000156026 9606 + 10:72692131-72887694 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000373053
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000373053 3.256±0.00 1.728±0.00 0.267±0.00 0.975±0.00 3.632±0.00 2.769±0.00 1.394±0.61 2.320±1.70 1.482±0.00 3.925±1.05 7.243±0.00 5.197±1.75 4.201±1.38 2.873±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008QA CIL_0008QA_0001 VISTA 10:72591086-73192639

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005262 IDA calcium channel activity
GO:0005515 IPI protein binding
GO:0005739 IEA mitochondrion
GO:0005743 IDA mitochondrial inner membrane
GO:0006851 IMP mitochondrial calcium ion transport
GO:0015292 IDA uniporter activity
GO:0019722 IDA calcium-mediated signaling
GO:0031305 IDA integral component of mitochondrial inner membrane
GO:0032024 IMP positive regulation of insulin secretion
GO:0034704 ISS calcium channel complex
GO:0035786 IDA protein complex oligomerization
GO:0036444 IDA calcium ion transmembrane import into mitochondrion
GO:0042593 IMP glucose homeostasis
GO:0042802 IEA identical protein binding
GO:0051560 IEA mitochondrial calcium ion homeostasis
GO:0051561 IMP positive regulation of mitochondrial calcium ion concentration
GO:0055085 IEA transmembrane transport
GO:1990246 IDA uniplex complex

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000020312 Mcu-001 protein_coding Mus_musculus 0 1386
ENSMUST00000009791 Mcu-004 protein_coding Mus_musculus 0 747
ENSMUST00000161168 Mcu-002 processed_transcript Mus_musculus 0 224
ENSMUST00000161435 Mcu-003 nonsense_mediated_decay Mus_musculus 0 219

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