C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: neuregulin 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000157168 NRG1 9606 + 8:31639386-32765040 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000287842 NRG1-004 32548267-32764511 protein_coding
  ENST00000356819 NRG1-201 32548210-32765040 protein_coding
  ENST00000405005 NRG1-017 32548727-32764471 protein_coding
  ENST00000518084 NRG1-012 32721753-32754423 protein_coding
  ENST00000518104 NRG1-009 31639386-32764022 protein_coding
  ENST00000518206 NRG1-007 32605648-32743224 protein_coding
  ENST00000519240 NRG1-014 32721845-32756475 protein_coding
  ENST00000519301 NRG1-008 31639386-32764405 protein_coding
  ENST00000520407 NRG1-001 31639755-32743224 protein_coding
  ENST00000520502 NRG1-011 32647718-32743207 protein_coding
  ENST00000521670 NRG1-006 32548619-32763998 protein_coding
  ENST00000522402 NRG1-013 32721819-32756447 protein_coding
  ENST00000522569 NRG1-015 32614375-32756528 retained_intron
  ENST00000523041 NRG1-010 32647838-32743221 protein_coding
  ENST00000523079 NRG1-003 32548210-32760989 protein_coding
  ENST00000523534 NRG1-002 31640426-32764776 protein_coding
  ENST00000523681 NRG1-016 32748824-32751155 processed_transcript
  ENST00000539990 NRG1-202 32721833-32765030 protein_coding
  ENST00000614767 NRG1-203 31639985-31641769 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000287842ENST00000356819ENST00000405005ENST00000518104ENST00000518206ENST00000519301ENST00000520407ENST00000520502ENST00000521670ENST00000522569ENST00000523041ENST00000523079ENST00000523534ENST00000523681ENST00000539990
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000287842 N/A N/A 0.757±0.00 N/A 0.148±0.00 N/A N/A 0.666±0.00 N/A 0.306±0.00 N/A 0.159±0.00 N/A 0.773±0.00
ENST00000356819 N/A 0.052±0.00 N/A N/A 0.374±0.00 N/A 0.153±0.00 N/A N/A 0.240±0.00 N/A 0.066±0.01 N/A N/A
ENST00000405005 N/A N/A N/A N/A N/A N/A 0.084±0.00 N/A 0.400±0.00 0.737±0.00 N/A 0.232±0.02 N/A N/A
ENST00000518104 0.022±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.069±0.00 0.160±0.00 N/A N/A
ENST00000518206 N/A 0.099±0.00 N/A N/A N/A N/A N/A N/A 0.256±0.00 N/A 0.149±0.00 0.169±0.01 0.056±0.00 1.769±0.46
ENST00000519301 N/A N/A N/A N/A N/A N/A 0.034±0.00 N/A N/A N/A N/A N/A 0.033±0.00 N/A
ENST00000520407 N/A N/A N/A 0.404±0.06 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000520502 0.044±0.00 N/A N/A 0.744±0.22 N/A N/A N/A N/A N/A N/A N/A N/A 0.034±0.00 N/A
ENST00000521670 N/A N/A N/A N/A N/A N/A N/A N/A 0.555±0.00 N/A N/A 0.151±0.00 N/A 0.935±0.00
ENST00000522569 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.043±0.00 N/A 0.663±0.00 0.183±0.00 N/A
ENST00000523041 N/A N/A N/A 0.654±0.00 N/A 0.249±0.00 0.103±0.00 N/A N/A N/A N/A 0.363±0.00 0.084±0.00 N/A
ENST00000523079 N/A N/A N/A N/A N/A N/A N/A 0.852±0.00 N/A N/A N/A 0.066±0.00 N/A 1.191±0.00
ENST00000523534 N/A N/A N/A 0.202±0.00 N/A N/A N/A N/A 0.072±0.00 N/A N/A N/A N/A N/A
ENST00000523681 N/A N/A N/A N/A N/A N/A N/A 0.528±0.00 N/A N/A N/A N/A N/A N/A
ENST00000539990 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.142±0.00 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000902 IEA cell morphogenesis
GO:0003161 IEA cardiac conduction system development
GO:0003222 IDA ventricular trabecula myocardium morphogenesis
GO:0003712 IDA transcription cofactor activity
GO:0005102 IPI:IEA receptor binding
GO:0005125 TAS cytokine activity
GO:0005176 IEA ErbB-2 class receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005576 NAS extracellular region
GO:0005615 IDA extracellular space
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005886 IEA plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0007154 TAS cell communication
GO:0007169 IDA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007171 NAS activation of transmembrane receptor protein tyrosine kinase activity
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007399 TAS nervous system development
GO:0007416 IEA synapse assembly
GO:0007422 IEA peripheral nervous system development
GO:0007507 IEA heart development
GO:0007517 IEA muscle organ development
GO:0007626 IEA locomotory behavior
GO:0008083 IDA growth factor activity
GO:0008283 IDA cell proliferation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009790 IEA embryo development
GO:0010001 IEA glial cell differentiation
GO:0010667 IDA negative regulation of cardiac muscle cell apoptotic process
GO:0014032 TAS neural crest cell development
GO:0016020 NAS membrane
GO:0016324 IDA apical plasma membrane
GO:0016477 IEA cell migration
GO:0021781 IEA glial cell fate commitment
GO:0030296 IDA protein tyrosine kinase activator activity
GO:0030297 NAS transmembrane receptor protein tyrosine kinase activator activity
GO:0030307 IDA positive regulation of cell growth
GO:0030424 IEA axon
GO:0030879 TAS mammary gland development
GO:0030971 NAS receptor tyrosine kinase binding
GO:0031594 IEA neuromuscular junction
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038127 IDA ERBB signaling pathway
GO:0042060 IDA wound healing
GO:0042177 IEA negative regulation of protein catabolic process
GO:0043125 IPI ErbB-3 class receptor binding
GO:0043496 TAS regulation of protein homodimerization activity
GO:0043497 IDA regulation of protein heterodimerization activity
GO:0043624 IGI cellular protein complex disassembly
GO:0045087 TAS innate immune response
GO:0045202 IEA synapse
GO:0045213 IEA neurotransmitter receptor metabolic process
GO:0045595 IEA regulation of cell differentiation
GO:0045785 IDA positive regulation of cell adhesion
GO:0045860 IEA positive regulation of protein kinase activity
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0046579 IEA positive regulation of Ras protein signal transduction
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048663 IEA neuron fate commitment
GO:0051048 IDA negative regulation of secretion
GO:0051155 ISS positive regulation of striated muscle cell differentiation
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0055007 ISS cardiac muscle cell differentiation
GO:0055012 IDA ventricular cardiac muscle cell differentiation
GO:0060045 IDA positive regulation of cardiac muscle cell proliferation
GO:0060379 IDA cardiac muscle cell myoblast differentiation
GO:0060956 IDA endocardial cell differentiation
GO:0061098 IDA positive regulation of protein tyrosine kinase activity
GO:2000727 IEA positive regulation of cardiac muscle cell differentiation
GO:2001240 IDA negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000068458 nrg1 neuregulin 1 protein_coding Danio_rerio
ENSMUSG00000062991 Nrg1 neuregulin 1 protein_coding Mus_musculus

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