C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: neuregulin 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000405005 NRG1-017 ENSG00000157168 9606 + 8:32548727-32764471 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; HeartLiverLungOvaryENST00000405005
Transcript ID Heart Liver Lung Ovary
ENST00000405005 0.084±0.00 0.400±0.00 0.737±0.00 0.232±0.02

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000902 IEA cell morphogenesis
GO:0003161 IEA cardiac conduction system development
GO:0003222 IDA ventricular trabecula myocardium morphogenesis
GO:0003712 IDA transcription cofactor activity
GO:0005102 IPI:IEA receptor binding
GO:0005125 TAS cytokine activity
GO:0005176 IEA ErbB-2 class receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005576 NAS extracellular region
GO:0005615 IDA extracellular space
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005886 IEA plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0007154 TAS cell communication
GO:0007169 IDA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007171 NAS activation of transmembrane receptor protein tyrosine kinase activity
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007399 TAS nervous system development
GO:0007416 IEA synapse assembly
GO:0007422 IEA peripheral nervous system development
GO:0007507 IEA heart development
GO:0007517 IEA muscle organ development
GO:0007626 IEA locomotory behavior
GO:0008083 IDA growth factor activity
GO:0008283 IDA cell proliferation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009790 IEA embryo development
GO:0010001 IEA glial cell differentiation
GO:0010667 IDA negative regulation of cardiac muscle cell apoptotic process
GO:0014032 TAS neural crest cell development
GO:0016020 NAS membrane
GO:0016324 IDA apical plasma membrane
GO:0016477 IEA cell migration
GO:0021781 IEA glial cell fate commitment
GO:0030296 IDA protein tyrosine kinase activator activity
GO:0030297 NAS transmembrane receptor protein tyrosine kinase activator activity
GO:0030307 IDA positive regulation of cell growth
GO:0030424 IEA axon
GO:0030879 TAS mammary gland development
GO:0030971 NAS receptor tyrosine kinase binding
GO:0031594 IEA neuromuscular junction
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038127 IDA ERBB signaling pathway
GO:0042060 IDA wound healing
GO:0042177 IEA negative regulation of protein catabolic process
GO:0043125 IPI ErbB-3 class receptor binding
GO:0043496 TAS regulation of protein homodimerization activity
GO:0043497 IDA regulation of protein heterodimerization activity
GO:0043624 IGI cellular protein complex disassembly
GO:0045087 TAS innate immune response
GO:0045202 IEA synapse
GO:0045213 IEA neurotransmitter receptor metabolic process
GO:0045595 IEA regulation of cell differentiation
GO:0045785 IDA positive regulation of cell adhesion
GO:0045860 IEA positive regulation of protein kinase activity
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0046579 IEA positive regulation of Ras protein signal transduction
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048663 IEA neuron fate commitment
GO:0051048 IDA negative regulation of secretion
GO:0051155 ISS positive regulation of striated muscle cell differentiation
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0055007 ISS cardiac muscle cell differentiation
GO:0055012 IDA ventricular cardiac muscle cell differentiation
GO:0060045 IDA positive regulation of cardiac muscle cell proliferation
GO:0060379 IDA cardiac muscle cell myoblast differentiation
GO:0060956 IDA endocardial cell differentiation
GO:0061098 IDA positive regulation of protein tyrosine kinase activity
GO:2000727 IEA positive regulation of cardiac muscle cell differentiation
GO:2001240 IDA negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000073884 Nrg1-201 protein_coding Mus_musculus 0 1596
ENSDART00000098696 nrg2a-001 protein_coding Danio_rerio 3e-26 124
ENSMUST00000115713 Nrg2-001 protein_coding Mus_musculus 1e-25 122
ENSMUST00000115712 Nrg2-003 protein_coding Mus_musculus 1e-24 119
ENSDART00000128237 nrg2a-203 protein_coding Danio_rerio 1e-24 119

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