C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: neuregulin 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000519301 NRG1-008 ENSG00000157168 9606 + 8:31639386-32764405 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; HeartPlacentaENST00000519301
Transcript ID Heart Placenta
ENST00000519301 0.034±0.00 0.033±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0003222 IDA ventricular trabecula myocardium morphogenesis
GO:0003712 IDA transcription cofactor activity
GO:0005102 IPI:IEA receptor binding
GO:0005125 TAS cytokine activity
GO:0005515 IPI:IEA protein binding
GO:0005576 NAS extracellular region
GO:0005615 IDA extracellular space
GO:0005634 IEA nucleus
GO:0007154 TAS cell communication
GO:0007169 IDA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007171 NAS activation of transmembrane receptor protein tyrosine kinase activity
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007399 TAS nervous system development
GO:0008083 IDA growth factor activity
GO:0008283 IDA cell proliferation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009790 IEA embryo development
GO:0010667 IDA negative regulation of cardiac muscle cell apoptotic process
GO:0014032 TAS neural crest cell development
GO:0016020 NAS membrane
GO:0016324 IDA apical plasma membrane
GO:0030296 IDA protein tyrosine kinase activator activity
GO:0030297 NAS transmembrane receptor protein tyrosine kinase activator activity
GO:0030307 IDA positive regulation of cell growth
GO:0030879 TAS mammary gland development
GO:0030971 NAS receptor tyrosine kinase binding
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038127 IDA ERBB signaling pathway
GO:0042060 IDA wound healing
GO:0043125 IPI ErbB-3 class receptor binding
GO:0043496 TAS regulation of protein homodimerization activity
GO:0043497 IDA regulation of protein heterodimerization activity
GO:0043624 IGI cellular protein complex disassembly
GO:0045087 TAS innate immune response
GO:0045785 IDA positive regulation of cell adhesion
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0051048 IDA negative regulation of secretion
GO:0051155 ISS positive regulation of striated muscle cell differentiation
GO:0055007 ISS cardiac muscle cell differentiation
GO:0055012 IDA ventricular cardiac muscle cell differentiation
GO:0060045 IDA positive regulation of cardiac muscle cell proliferation
GO:0060379 IDA cardiac muscle cell myoblast differentiation
GO:0060956 IDA endocardial cell differentiation
GO:0061098 IDA positive regulation of protein tyrosine kinase activity
GO:2001240 IDA negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000073884 Nrg1-201 protein_coding Mus_musculus 0 1929
ENSDART00000128237 nrg2a-203 protein_coding Danio_rerio 0 209
ENSDART00000098696 nrg2a-001 protein_coding Danio_rerio 1e-24 119
ENSMUST00000115712 Nrg2-003 protein_coding Mus_musculus 4e-24 117
ENSMUST00000115713 Nrg2-001 protein_coding Mus_musculus 4e-24 117

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