C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: matrix metallopeptidase 14 (membrane-inserted)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000157227 MMP14 9606 + 14:22836557-22849027 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000311852 MMP14-001 22836557-22847761 protein_coding
  ENST00000547074 MMP14-005 22836560-22841684 retained_intron
  ENST00000547279 MMP14-006 22836620-22837286 non_stop_decay
  ENST00000547596 MMP14-008 22841621-22842468 retained_intron
  ENST00000548162 MMP14-003 22836576-22849027 processed_transcript
  ENST00000548761 MMP14-007 22837312-22842593 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000311852ENST00000548162
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000311852 99.486±0.00 25.228±0.00 1.491±0.00 2.113±1.56 16.433±9.60 39.445±36.16 3.479±2.87 1.560±0.57 3.552±0.60 2.173±0.00 4.140±3.56 57.497±39.17 157.732±42.71 23.343±17.28
ENST00000548162 N/A N/A N/A 0.968±0.00 15.026±0.00 0.959±0.00 0.783±0.00 N/A 4.388±0.00 2.976±0.00 0.229±0.00 3.508±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004Z1 CIL_0004Z1_0002 CGP 14:22829879-22849027
CIL_0004Z6 CIL_0004Z6_0002 CGP 14:22836557-22881580

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001503 IEA ossification
GO:0001525 IEA angiogenesis
GO:0001541 IEA ovarian follicle development
GO:0001666 IEA response to hypoxia
GO:0001935 IEA endothelial cell proliferation
GO:0001958 IEA endochondral ossification
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0004222 IEA metalloendopeptidase activity
GO:0005178 IEA integrin binding
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005796 TAS Golgi lumen
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0005925 IDA focal adhesion
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006508 IEA proteolysis
GO:0006979 IEA response to oxidative stress
GO:0008237 IEA metallopeptidase activity
GO:0008270 IEA zinc ion binding
GO:0008584 IEA male gonad development
GO:0009612 IEA response to mechanical stimulus
GO:0009725 IEA response to hormone
GO:0010952 IEA positive regulation of peptidase activity
GO:0014070 IEA response to organic cyclic compound
GO:0016477 IEA cell migration
GO:0016504 IEA peptidase activator activity
GO:0022617 TAS extracellular matrix disassembly
GO:0030198 TAS extracellular matrix organization
GO:0030307 IDA positive regulation of cell growth
GO:0030324 IEA lung development
GO:0030335 IDA positive regulation of cell migration
GO:0030574 TAS collagen catabolic process
GO:0031012 IEA extracellular matrix
GO:0031638 IEA zymogen activation
GO:0035987 IEP endodermal cell differentiation
GO:0035988 IEA chondrocyte proliferation
GO:0043615 IEA astrocyte cell migration
GO:0043627 IEA response to estrogen
GO:0048701 IEA embryonic cranial skeleton morphogenesis
GO:0048754 IEA branching morphogenesis of an epithelial tube
GO:0048771 IEA tissue remodeling
GO:0051895 IEA negative regulation of focal adhesion assembly
GO:0060348 IEA bone development
GO:0097094 IEA craniofacial suture morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000002235 mmp14a matrix metalloproteinase 14a (membrane-inserted) protein_coding Danio_rerio
ENSDARG00000008388 mmp14b matrix metalloproteinase 14b (membrane-inserted) protein_coding Danio_rerio
ENSMUSG00000000957 Mmp14 matrix metallopeptidase 14 (membrane-inserted) protein_coding Mus_musculus

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