C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: calcium channel, voltage-dependent, L type, alpha 1D subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000157388 CACNA1D 9606 + 3:53494656-53813733 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000288139 CACNA1D-001 53495049-53813733 protein_coding
  ENST00000350061 CACNA1D-003 53494656-53812045 protein_coding
  ENST00000422281 CACNA1D-002 53495167-53811406 protein_coding
  ENST00000464429 CACNA1D-006 53666378-53674047 retained_intron
  ENST00000481085 CACNA1D-007 53666363-53722458 protein_coding
  ENST00000481478 CACNA1D-004 53666401-53811508 protein_coding
  ENST00000498251 CACNA1D-005 53673061-53679763 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainBreastColonHeartKidneyLungOvaryPlacentaTestisENST00000288139ENST00000350061ENST00000422281ENST00000481478ENST00000498251
Transcript ID Adipose Brain Breast Colon Heart Kidney Lung Ovary Placenta Testis
ENST00000288139 N/A 0.827±0.07 0.377±0.00 N/A N/A 0.954±0.00 0.590±0.00 0.362±0.05 0.081±0.03 N/A
ENST00000350061 N/A N/A N/A 0.251±0.00 N/A N/A 0.437±0.00 N/A 0.121±0.00 0.909±0.00
ENST00000422281 N/A 1.461±0.00 0.564±0.00 0.978±0.00 0.043±0.00 N/A 0.367±0.00 0.461±0.00 0.134±0.00 1.041±0.00
ENST00000481478 N/A N/A 0.543±0.00 N/A N/A 0.595±0.00 0.617±0.00 N/A 0.142±0.00 N/A
ENST00000498251 0.305±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005216 IEA ion channel activity
GO:0005245 IDA voltage-gated calcium channel activity
GO:0005515 IEA protein binding
GO:0005886 ISS plasma membrane
GO:0005891 IDA voltage-gated calcium channel complex
GO:0006112 TAS energy reserve metabolic process
GO:0006811 IEA ion transport
GO:0006816 IDA calcium ion transport
GO:0007188 ISS adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007411 TAS axon guidance
GO:0007605 IMP sensory perception of sound
GO:0008331 IDA high voltage-gated calcium channel activity
GO:0016020 IEA membrane
GO:0030018 ISS Z disc
GO:0030506 ISS ankyrin binding
GO:0034765 IEA regulation of ion transmembrane transport
GO:0044281 TAS small molecule metabolic process
GO:0046872 IEA metal ion binding
GO:0050796 TAS regulation of insulin secretion
GO:0051393 IPI alpha-actinin binding
GO:0051928 IDA positive regulation of calcium ion transport
GO:0055085 IEA transmembrane transport
GO:0060372 ISS regulation of atrial cardiac muscle cell membrane repolarization
GO:0070509 IDA calcium ion import
GO:0070588 ISS calcium ion transmembrane transport
GO:0086007 IC voltage-gated calcium channel activity involved in cardiac muscle cell action potential
GO:0086010 IBA membrane depolarization during action potential
GO:0086012 IC membrane depolarization during cardiac muscle cell action potential
GO:0086046 IEA membrane depolarization during SA node cell action potential
GO:0086052 IMP membrane repolarization during SA node cell action potential
GO:0086059 IMP voltage-gated calcium channel activity involved SA node cell action potential
GO:0086091 IMP regulation of heart rate by cardiac conduction
GO:1901016 ISS regulation of potassium ion transmembrane transporter activity
GO:1901379 ISS regulation of potassium ion transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000024004 cacna1da calcium channel, voltage-dependent, L type, alpha 1D subunit, a protein_coding Danio_rerio
ENSMUSG00000015968 Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit protein_coding Mus_musculus

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