C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000157500 APPL1 9606 + 3:57227737-57273468 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000288266 APPL1-001 57227737-57273468 protein_coding
  ENST00000444459 APPL1-002 57227874-57242892 protein_coding
  ENST00000464446 APPL1-003 57253682-57260439 retained_intron
  ENST00000468342 APPL1-007 57227839-57238205 retained_intron
  ENST00000482800 APPL1-005 57227789-57268021 retained_intron
  ENST00000488530 APPL1-004 57258763-57267792 retained_intron
  ENST00000492501 APPL1-006 57259793-57260434 retained_intron
  ENST00000495803 APPL1-008 57227831-57242142 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000288266ENST00000464446ENST00000482800
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000288266 7.399±0.00 5.318±0.00 6.078±0.00 9.248±3.90 7.990±3.13 8.000±3.13 5.476±1.73 3.233±2.53 7.316±5.27 5.995±1.99 6.457±1.43 7.561±2.89 4.453±2.67 6.076±0.00
ENST00000464446 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 21.146±0.00 N/A N/A N/A
ENST00000482800 N/A N/A N/A 4.027±0.00 N/A N/A N/A N/A N/A N/A 6.472±0.00 N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IC cytoplasm
GO:0005829 IDA cytosol
GO:0006915 TAS apoptotic process
GO:0007049 IEA cell cycle
GO:0007165 TAS signal transduction
GO:0008283 IDA cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0010008 IDA endosome membrane
GO:0012506 IDA vesicle membrane
GO:0016581 IDA NuRD complex
GO:0042802 IPI identical protein binding
GO:0042981 TAS regulation of apoptotic process
GO:0043065 TAS positive regulation of apoptotic process
GO:0043422 IPI protein kinase B binding
GO:0046324 IMP regulation of glucose import
GO:0070062 IDA extracellular vesicular exosome
GO:0090003 IMP regulation of establishment of protein localization to plasma membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060734 appl1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 protein_coding Danio_rerio
ENSMUSG00000040760 Appl1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 protein_coding Mus_musculus

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