C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000288266 APPL1-001 ENSG00000157500 9606 + 3:57227737-57273468 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000288266
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000288266 7.399±0.00 5.318±0.00 6.078±0.00 9.248±3.90 7.990±3.13 8.000±3.13 5.476±1.73 3.233±2.53 7.316±5.27 5.995±1.99 6.457±1.43 7.561±2.89 4.453±2.67 6.076±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IC cytoplasm
GO:0005829 IDA cytosol
GO:0006915 TAS apoptotic process
GO:0007049 IEA cell cycle
GO:0007165 TAS signal transduction
GO:0008283 IDA cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0010008 IDA endosome membrane
GO:0012506 IDA vesicle membrane
GO:0016581 IDA NuRD complex
GO:0042802 IPI identical protein binding
GO:0042981 TAS regulation of apoptotic process
GO:0043065 TAS positive regulation of apoptotic process
GO:0043422 IPI protein kinase B binding
GO:0046324 IMP regulation of glucose import
GO:0070062 IDA extracellular vesicular exosome
GO:0090003 IMP regulation of establishment of protein localization to plasma membrane

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000036570 Appl1-001 protein_coding Mus_musculus 0 3103
ENSMUST00000142645 Appl1-002 retained_intron Mus_musculus 0 902
ENSMUST00000142261 Appl1-003 retained_intron Mus_musculus 0 424
ENSMUST00000141599 Appl1-004 retained_intron Mus_musculus 0 379

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