C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000040760 Appl1 10090 - 14:26918988-26971232 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000036570 Appl1-001 26918988-26971232 protein_coding
  ENSMUST00000141599 Appl1-004 26951126-26958511 retained_intron
  ENSMUST00000142261 Appl1-003 26962597-26970463 retained_intron
  ENSMUST00000142645 Appl1-002 26952419-26970500 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000036570
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000036570 4.790±1.86 4.495±1.89 3.772±0.69 7.935±0.17 3.582±1.51 2.978±1.08 2.466±0.45 2.978±0.18 1.520±0.43 3.719±1.63 2.565±0.65 5.204±2.05 7.304±2.33 2.693±0.62

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000CD CIL_0000CD_0002 CGP 14:26894557-26971232
CIL_0000CC CIL_0000CC_0002 CGP 14:26918988-27002329

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005634 ISS nucleus
GO:0005829 IEA cytosol
GO:0007049 IEA cell cycle
GO:0008283 ISS cell proliferation
GO:0010008 ISS endosome membrane
GO:0012506 IEA vesicle membrane
GO:0016581 ISS NuRD complex
GO:0042802 IEA identical protein binding
GO:0043422 IEA protein kinase B binding
GO:0046324 IEA regulation of glucose import
GO:0070062 IEA extracellular vesicular exosome
GO:0090003 IEA regulation of establishment of protein localization to plasma membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060734 appl1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 protein_coding Danio_rerio
ENSG00000157500 APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 protein_coding Homo_sapiens

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