C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: low density lipoprotein receptor adaptor protein 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000157978 LDLRAP1 9606 + 1:25543580-25568886 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000374338 LDLRAP1-001 25543580-25568886 protein_coding
  ENST00000462394 LDLRAP1-007 25554881-25557429 processed_transcript
  ENST00000470950 LDLRAP1-003 25564591-25567636 processed_transcript
  ENST00000474283 LDLRAP1-005 25563634-25567570 processed_transcript
  ENST00000484476 LDLRAP1-004 25562816-25567000 processed_transcript
  ENST00000485476 LDLRAP1-006 25549961-25554879 processed_transcript
  ENST00000488127 LDLRAP1-002 25553364-25568884 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000374338ENST00000462394ENST00000474283ENST00000485476ENST00000488127
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000374338 4.170±0.00 6.728±0.00 0.368±0.00 4.592±3.63 5.433±5.04 3.850±1.98 1.693±1.38 4.818±3.95 2.398±2.03 3.798±2.71 2.102±1.70 10.173±6.86 19.133±5.28 6.228±1.18
ENST00000462394 N/A N/A N/A N/A 1.953±0.00 N/A N/A N/A N/A 2.992±0.00 N/A N/A N/A N/A
ENST00000474283 N/A N/A N/A N/A N/A N/A N/A 0.872±0.00 N/A N/A N/A N/A N/A N/A
ENST00000485476 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.279±0.00 N/A N/A N/A
ENST00000488127 N/A N/A N/A 0.126±0.00 0.223±0.00 N/A N/A N/A 0.096±0.00 0.806±0.28 0.413±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003Q1 CIL_0003Q1_0003 CGP 1:25430858-25568886

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001540 IPI beta-amyloid binding
GO:0001784 IDA phosphotyrosine binding
GO:0005515 IPI:IEA protein binding
GO:0005546 IDA phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 IEA cytoplasm
GO:0005769 IDA early endosome
GO:0005829 IDA cytosol
GO:0005883 ISS neurofilament
GO:0006810 NAS transport
GO:0006898 IDA receptor-mediated endocytosis
GO:0008203 NAS cholesterol metabolic process
GO:0009898 IDA cytoplasmic side of plasma membrane
GO:0009925 IDA basal plasma membrane
GO:0009967 IDA positive regulation of signal transduction
GO:0030121 IDA AP-1 adaptor complex
GO:0030122 IDA AP-2 adaptor complex
GO:0030159 IMP receptor signaling complex scaffold activity
GO:0030276 IDA clathrin binding
GO:0030424 ISS axon
GO:0031623 IMP receptor internalization
GO:0035591 IDA signaling adaptor activity
GO:0035612 IDA AP-2 adaptor complex binding
GO:0035615 IDA clathrin adaptor activity
GO:0042632 IMP cholesterol homeostasis
GO:0042982 IMP amyloid precursor protein metabolic process
GO:0043393 IMP regulation of protein binding
GO:0048260 IMP positive regulation of receptor-mediated endocytosis
GO:0050750 IPI low-density lipoprotein particle receptor binding
GO:0055037 IDA recycling endosome
GO:0090003 IMP regulation of establishment of protein localization to plasma membrane
GO:0090118 IMP receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
GO:0090205 IC positive regulation of cholesterol metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004311 ldlrap1a low density lipoprotein receptor adaptor protein 1a protein_coding Danio_rerio
ENSDARG00000039750 ldlrap1b low density lipoprotein receptor adaptor protein 1b protein_coding Danio_rerio
ENSMUSG00000037295 Ldlrap1 low density lipoprotein receptor adaptor protein 1 protein_coding Mus_musculus

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