C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: low density lipoprotein receptor adaptor protein 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000374338 LDLRAP1-001 ENSG00000157978 9606 + 1:25543580-25568886 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000374338
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000374338 4.170±0.00 6.728±0.00 0.368±0.00 4.592±3.63 5.433±5.04 3.850±1.98 1.693±1.38 4.818±3.95 2.398±2.03 3.798±2.71 2.102±1.70 10.173±6.86 19.133±5.28 6.228±1.18

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003Q1 CIL_0003Q1_0003 CGP 1:25430858-25568886

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001540 IPI beta-amyloid binding
GO:0001784 IDA phosphotyrosine binding
GO:0005515 IPI:IEA protein binding
GO:0005546 IDA phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 IEA cytoplasm
GO:0005769 IDA early endosome
GO:0005829 IDA cytosol
GO:0005883 ISS neurofilament
GO:0006810 NAS transport
GO:0006898 IDA receptor-mediated endocytosis
GO:0008203 NAS cholesterol metabolic process
GO:0009898 IDA cytoplasmic side of plasma membrane
GO:0009925 IDA basal plasma membrane
GO:0009967 IDA positive regulation of signal transduction
GO:0030121 IDA AP-1 adaptor complex
GO:0030122 IDA AP-2 adaptor complex
GO:0030159 IMP receptor signaling complex scaffold activity
GO:0030276 IDA clathrin binding
GO:0030424 ISS axon
GO:0031623 IMP receptor internalization
GO:0035591 IDA signaling adaptor activity
GO:0035612 IDA AP-2 adaptor complex binding
GO:0035615 IDA clathrin adaptor activity
GO:0042632 IMP cholesterol homeostasis
GO:0042982 IMP amyloid precursor protein metabolic process
GO:0043393 IMP regulation of protein binding
GO:0048260 IMP positive regulation of receptor-mediated endocytosis
GO:0050750 IPI low-density lipoprotein particle receptor binding
GO:0055037 IDA recycling endosome
GO:0090003 IMP regulation of establishment of protein localization to plasma membrane
GO:0090118 IMP receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
GO:0090205 IC positive regulation of cholesterol metabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000037828 Ldlrap1-001 protein_coding Mus_musculus 0 1061
ENSMUST00000140678 Ldlrap1-003 retained_intron Mus_musculus 0 202

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