C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NCK adaptor protein 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000158092 NCK1 9606 + 3:136862208-136949823 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000288986 NCK1-001 136862208-136949126 protein_coding
  ENST00000460960 NCK1-007 136862267-136928473 retained_intron
  ENST00000467911 NCK1-011 136930502-136948432 protein_coding
  ENST00000469404 NCK1-002 136930470-136949823 protein_coding
  ENST00000476286 NCK1-006 136862264-136928227 protein_coding
  ENST00000478862 NCK1-008 136862267-136928724 retained_intron
  ENST00000481752 NCK1-003 136862208-136949126 protein_coding
  ENST00000482071 NCK1-012 136945725-136947047 retained_intron
  ENST00000485096 NCK1-005 136862242-136945702 protein_coding
  ENST00000488930 NCK1-009 136862298-136946218 protein_coding
  ENST00000491539 NCK1-004 136862233-136945743 protein_coding
  ENST00000496489 NCK1-010 136928039-136946214 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000288986ENST00000469404ENST00000481752ENST00000482071ENST00000488930ENST00000496489
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000288986 6.771±0.00 7.326±0.00 N/A 1.100±0.00 2.689±0.00 5.495±1.89 2.017±1.33 4.845±0.00 4.546±0.66 5.124±0.00 3.350±0.00 4.083±2.65 4.409±1.94 4.996±2.60
ENST00000469404 1.742±0.00 3.313±0.00 N/A 1.054±0.00 1.997±0.00 1.991±1.28 0.730±0.50 N/A 0.646±0.00 2.935±0.69 N/A 2.685±0.14 1.979±0.17 N/A
ENST00000481752 N/A N/A 0.699±0.00 2.218±0.00 7.013±0.00 N/A N/A N/A N/A 4.342±0.00 N/A 2.372±0.10 1.681±0.74 2.616±0.00
ENST00000482071 9.414±0.00 N/A N/A 2.262±0.00 N/A N/A N/A 3.092±0.00 N/A N/A N/A N/A 2.845±0.00 9.203±0.00
ENST00000488930 N/A N/A 1.620±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 6.045±0.00 N/A N/A
ENST00000496489 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.845±0.00 N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004860 IDA protein kinase inhibitor activity
GO:0005102 IPI receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005634 IEA nucleus
GO:0005737 NAS cytoplasm
GO:0005783 IEA endoplasmic reticulum
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0005911 IEA cell-cell junction
GO:0006417 IEA regulation of translation
GO:0006469 IDA negative regulation of protein kinase activity
GO:0006930 IEA substrate-dependent cell migration, cell extension
GO:0007015 IEA actin filament organization
GO:0007172 NAS signal complex assembly
GO:0007411 TAS axon guidance
GO:0008093 NAS cytoskeletal adaptor activity
GO:0012506 IEA vesicle membrane
GO:0016477 IEA cell migration
GO:0019887 IEA protein kinase regulator activity
GO:0019904 IEA protein domain specific binding
GO:0030032 IEA lamellipodium assembly
GO:0030159 NAS receptor signaling complex scaffold activity
GO:0030838 IMP positive regulation of actin filament polymerization
GO:0030971 IPI receptor tyrosine kinase binding
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042102 IMP positive regulation of T cell proliferation
GO:0042110 IMP T cell activation
GO:0045087 TAS innate immune response
GO:0045859 IEA regulation of protein kinase activity
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0050852 TAS T cell receptor signaling pathway
GO:0051707 IEA response to other organism
GO:0060548 IDA negative regulation of cell death

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074262 nck1a NCK adaptor protein 1a protein_coding Danio_rerio
ENSDARG00000075369 nck1b NCK adaptor protein 1b protein_coding Danio_rerio
ENSMUSG00000032475 Nck1 non-catalytic region of tyrosine kinase adaptor protein 1 protein_coding Mus_musculus

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