C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: non-catalytic region of tyrosine kinase adaptor protein 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000032475 Nck1 10090 - 9:100492293-100546134 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000112874 Nck1-002 100495003-100506856 protein_coding
  ENSMUST00000116522 Nck1-001 100492293-100546134 protein_coding
  ENSMUST00000186591 Nck1-006 100497577-100546122 protein_coding
  ENSMUST00000188670 Nck1-003 100497800-100545731 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000112874ENSMUST00000116522ENSMUST00000186591
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000112874 6.386±1.12 N/A 9.229±4.01 6.454±1.79 4.281±1.06 1.645±0.88 4.977±0.91 2.420±0.45 4.461±3.19 5.264±1.56 6.098±1.72 8.927±8.30 14.323±2.96 5.085±1.49
ENSMUST00000116522 1.223±0.21 1.092±0.17 1.195±0.51 1.364±0.83 1.135±0.32 1.870±0.37 0.920±0.16 1.290±0.36 1.483±0.48 3.267±0.71 0.654±0.07 2.040±0.89 2.661±0.01 1.713±0.58
ENSMUST00000186591 N/A N/A 6.796±0.00 4.774±0.40 N/A N/A N/A N/A 4.332±0.33 N/A 4.099±0.00 9.639±1.29 9.602±2.63 8.240±4.96

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00092I CIL_00092I_0002 VISTA 9:99894020-100495329
CIL_0009A5 CIL_0009A5_0002 VISTA 9:99910151-100511937
CIL_0009A4 CIL_0009A4_0002 VISTA 9:99971528-100572973
CIL_0001BW CIL_0001BW_0003 CGP 9:100492293-100571090

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004860 ISS protein kinase inhibitor activity
GO:0005102 IEA receptor binding
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005783 IEA endoplasmic reticulum
GO:0005911 IDA cell-cell junction
GO:0006417 IEA regulation of translation
GO:0006469 IEA negative regulation of protein kinase activity
GO:0006930 IGI substrate-dependent cell migration, cell extension
GO:0007015 IMP actin filament organization
GO:0012506 IDA vesicle membrane
GO:0016301 IEA kinase activity
GO:0016310 IEA phosphorylation
GO:0016477 IMP cell migration
GO:0019887 IEA protein kinase regulator activity
GO:0019904 IPI protein domain specific binding
GO:0030032 IMP lamellipodium assembly
GO:0030838 IGI positive regulation of actin filament polymerization
GO:0030971 IEA receptor tyrosine kinase binding
GO:0042102 IEA positive regulation of T cell proliferation
GO:0042110 IEA T cell activation
GO:0045859 IEA regulation of protein kinase activity
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0051707 IMP response to other organism
GO:0060548 ISS negative regulation of cell death

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074262 nck1a NCK adaptor protein 1a protein_coding Danio_rerio
ENSDARG00000075369 nck1b NCK adaptor protein 1b protein_coding Danio_rerio
ENSG00000158092 NCK1 NCK adaptor protein 1 protein_coding Homo_sapiens

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