C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: neutrophil cytosolic factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000158517 NCF1 9606 + 7:74773962-74789315 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000289473 NCF1-001 74773962-74789313 protein_coding
  ENST00000398421 NCF1-002 74774011-74789314 retained_intron
  ENST00000433458 NCF1-014 74777269-74782980 protein_coding
  ENST00000438106 NCF1-015 74777267-74781622 processed_transcript
  ENST00000442021 NCF1-011 74777269-74780802 protein_coding
  ENST00000443956 NCF1-003 74776809-74785292 processed_transcript
  ENST00000449343 NCF1-007 74774011-74783540 retained_intron
  ENST00000455062 NCF1-009 74777269-74789315 retained_intron
  ENST00000464878 NCF1-016 74777269-74783583 nonsense_mediated_decay
  ENST00000486097 NCF1-004 74783443-74785546 retained_intron
  ENST00000488197 NCF1-012 74780396-74783405 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000289473ENST00000398421ENST00000442021ENST00000443956ENST00000449343ENST00000455062ENST00000486097ENST00000488197
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000289473 0.318±0.00 1.067±0.00 N/A N/A 0.174±0.00 N/A 0.158±0.00 N/A N/A N/A N/A 0.424±0.39 5.546±0.75 N/A
ENST00000398421 0.332±0.00 1.390±0.00 N/A N/A 0.127±0.00 0.096±0.00 0.033±0.00 N/A N/A 0.110±0.00 N/A 0.107±0.07 N/A 0.093±0.01
ENST00000442021 N/A N/A N/A 0.227±0.00 0.374±0.00 0.274±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000443956 N/A 1.467±0.00 0.278±0.00 0.121±0.02 0.308±0.00 0.165±0.00 N/A 0.512±0.12 0.136±0.00 0.229±0.08 0.072±0.00 0.771±0.58 7.058±0.00 0.281±0.01
ENST00000449343 N/A N/A N/A N/A 0.489±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000455062 N/A N/A N/A N/A N/A N/A 0.080±0.00 N/A N/A 0.492±0.00 N/A 0.192±0.00 N/A N/A
ENST00000486097 1.140±0.00 4.545±0.00 0.530±0.00 0.251±0.00 1.495±0.00 0.716±0.00 N/A N/A 0.310±0.00 N/A 0.189±0.00 N/A N/A 0.907±0.00
ENST00000488197 N/A N/A N/A 0.238±0.00 0.183±0.00 0.079±0.00 0.095±0.00 0.075±0.00 0.244±0.00 N/A N/A 0.078±0.00 N/A 0.197±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001878 IEA response to yeast
GO:0001909 IEA leukocyte mediated cytotoxicity
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002679 IEA respiratory burst involved in defense response
GO:0005515 IPI:IEA protein binding
GO:0005737 IEA cytoplasm
GO:0005791 IEA rough endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0005829 IDA cytosol
GO:0005886 IEA plasma membrane
GO:0006612 IDA protein targeting to membrane
GO:0006691 IEA leukotriene metabolic process
GO:0006801 TAS superoxide metabolic process
GO:0006915 IEA apoptotic process
GO:0006954 IEA inflammatory response
GO:0006968 IEA cellular defense response
GO:0008283 IEA cell proliferation
GO:0009055 TAS electron carrier activity
GO:0009617 IEA response to bacterium
GO:0016020 IEA membrane
GO:0016175 IMP superoxide-generating NADPH oxidase activity
GO:0017124 IPI SH3 domain binding
GO:0019898 IDA extrinsic component of membrane
GO:0030425 IEA dendrite
GO:0032010 TAS phagolysosome
GO:0035091 IDA:IEA phosphatidylinositol binding
GO:0042554 IMP superoxide anion generation
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042742 IEA defense response to bacterium
GO:0043020 IDA NADPH oxidase complex
GO:0043025 IEA neuronal cell body
GO:0043325 IDA phosphatidylinositol-3,4-bisphosphate binding
GO:0045087 TAS innate immune response
GO:0045730 TAS respiratory burst
GO:0045986 IEA negative regulation of smooth muscle contraction
GO:0050665 IEA hydrogen peroxide biosynthetic process
GO:0050830 IEA defense response to Gram-positive bacterium
GO:0050832 IEA defense response to fungus
GO:0051701 TAS interaction with host
GO:0055114 IEA oxidation-reduction process
GO:0070946 IEA neutrophil mediated killing of gram-positive bacterium
GO:0070947 IEA neutrophil mediated killing of fungus
GO:0090382 TAS phagosome maturation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000033735 ncf1 neutrophil cytosolic factor 1 protein_coding Danio_rerio
ENSMUSG00000015950 Ncf1 neutrophil cytosolic factor 1 protein_coding Mus_musculus

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