C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dematin actin binding protein
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000158856 DMTN 9606 + 8:22048995-22082527 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000265800 DMTN-001 22057865-22082527 protein_coding
  ENST00000358242 DMTN-201 22059175-22082524 protein_coding
  ENST00000381470 DMTN-202 22053570-22082524 protein_coding
  ENST00000415253 DMTN-008 22059348-22082518 protein_coding
  ENST00000432128 DMTN-203 22054817-22082524 protein_coding
  ENST00000443491 DMTN-004 22054902-22082524 protein_coding
  ENST00000517305 DMTN-204 22057865-22082524 protein_coding
  ENST00000517418 DMTN-019 22057888-22070334 protein_coding
  ENST00000517600 DMTN-007 22054931-22081686 protein_coding
  ENST00000517804 DMTN-018 22056966-22070334 protein_coding
  ENST00000518816 DMTN-005 22054907-22070305 retained_intron
  ENST00000519333 DMTN-021 22066516-22069063 protein_coding
  ENST00000519850 DMTN-015 22053570-22069456 protein_coding
  ENST00000519907 DMTN-010 22059223-22082524 protein_coding
  ENST00000519959 DMTN-014 22053555-22066819 retained_intron
  ENST00000520174 DMTN-017 22056905-22072450 protein_coding
  ENST00000520856 DMTN-006 22054953-22069262 retained_intron
  ENST00000522148 DMTN-012 22048995-22069056 protein_coding
  ENST00000522340 DMTN-022 22066498-22067648 protein_coding
  ENST00000523266 DMTN-009 22059206-22082518 protein_coding
  ENST00000523300 DMTN-013 22049149-22070292 protein_coding
  ENST00000523623 DMTN-016 22055457-22070249 protein_coding
  ENST00000523782 DMTN-011 22054943-22082518 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000265800ENST00000358242ENST00000381470ENST00000415253ENST00000443491ENST00000517600ENST00000517804ENST00000519907ENST00000520174ENST00000522148ENST00000523266ENST00000523300ENST00000523782
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000265800 N/A N/A N/A 21.833±0.00 N/A 2.508±2.02 0.528±0.00 N/A N/A N/A N/A 3.663±0.00 4.024±0.00 1.780±0.00
ENST00000358242 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.234±0.00
ENST00000381470 N/A N/A N/A N/A N/A 0.518±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000415253 N/A N/A N/A N/A N/A 5.075±0.00 5.655±0.00 N/A 1.924±0.00 0.885±0.00 N/A 4.443±0.00 2.138±0.00 1.895±0.00
ENST00000443491 N/A N/A N/A 7.665±0.00 N/A N/A N/A N/A N/A N/A N/A 1.665±0.00 N/A N/A
ENST00000517600 N/A 2.773±0.00 N/A 52.273±0.00 14.643±12.69 11.750±0.00 N/A 14.705±0.00 N/A 0.514±0.00 N/A 2.923±1.32 1.577±0.00 2.952±0.63
ENST00000517804 N/A N/A N/A N/A N/A N/A N/A N/A 1.425±0.00 2.059±0.00 1.754±0.00 N/A N/A N/A
ENST00000519907 2.339±0.00 N/A N/A N/A N/A N/A 0.419±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000520174 N/A N/A 15.750±0.00 13.387±0.00 N/A N/A N/A N/A 1.191±0.00 1.736±0.00 2.774±0.00 N/A N/A N/A
ENST00000522148 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.641±0.00 N/A N/A
ENST00000523266 N/A N/A N/A N/A 6.879±0.00 N/A N/A N/A N/A N/A N/A 2.074±0.00 N/A N/A
ENST00000523300 N/A N/A 16.962±0.00 41.259±0.00 N/A 3.976±0.00 N/A 5.136±0.00 N/A N/A N/A N/A N/A N/A
ENST00000523782 4.883±0.00 4.857±0.00 N/A 32.464±28.41 23.750±0.00 10.599±0.00 N/A 13.569±0.00 0.170±0.00 15.825±0.00 8.389±0.00 2.501±0.43 3.343±0.00 2.203±0.09

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000810 CIL_000810_0001 VISTA 8:21687877-22288944
CIL_0008ZI CIL_0008ZI_0001 VISTA 8:21743578-22344815
CIL_000812 CIL_000812_0001 VISTA 8:21749915-22350771

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003779 IDA:IEA actin binding
GO:0005102 IDA receptor binding
GO:0005515 IPI protein binding
GO:0005829 IDA cytosol
GO:0005884 IDA actin filament
GO:0005886 IDA plasma membrane
GO:0006461 ISS protein complex assembly
GO:0007010 TAS:IEA cytoskeleton organization
GO:0008360 IMP regulation of cell shape
GO:0010591 IMP regulation of lamellipodium assembly
GO:0010763 ISS positive regulation of fibroblast migration
GO:0010801 ISS negative regulation of peptidyl-threonine phosphorylation
GO:0010812 ISS negative regulation of cell-substrate adhesion
GO:0014731 IDA spectrin-associated cytoskeleton
GO:0015629 TAS actin cytoskeleton
GO:0016020 IEA membrane
GO:0016023 IDA cytoplasmic membrane-bounded vesicle
GO:0030036 ISS actin cytoskeleton organization
GO:0030194 ISS positive regulation of blood coagulation
GO:0030507 IDA spectrin binding
GO:0030863 IEA cortical cytoskeleton
GO:0031095 IDA platelet dense tubular network membrane
GO:0031253 ISS cell projection membrane
GO:0032956 IDA regulation of actin cytoskeleton organization
GO:0033137 ISS negative regulation of peptidyl-serine phosphorylation
GO:0035584 ISS calcium-mediated signaling using intracellular calcium source
GO:0035585 ISS calcium-mediated signaling using extracellular calcium source
GO:0043621 IDA protein self-association
GO:0048471 ISS perinuclear region of cytoplasm
GO:0048821 ISS erythrocyte development
GO:0050732 ISS negative regulation of peptidyl-tyrosine phosphorylation
GO:0051017 IDA actin filament bundle assembly
GO:0051489 IMP regulation of filopodium assembly
GO:0051693 IEA actin filament capping
GO:0051895 ISS negative regulation of focal adhesion assembly
GO:0070560 ISS protein secretion by platelet
GO:0071277 ISS cellular response to calcium ion
GO:0071320 IDA cellular response to cAMP
GO:0090303 ISS positive regulation of wound healing
GO:0090315 ISS negative regulation of protein targeting to membrane
GO:0090527 ISS actin filament reorganization
GO:1900025 ISS negative regulation of substrate adhesion-dependent cell spreading
GO:1900026 ISS positive regulation of substrate adhesion-dependent cell spreading
GO:1901731 ISS positive regulation of platelet aggregation
GO:2001046 ISS positive regulation of integrin-mediated signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013110 dmtn dematin actin binding protein protein_coding Danio_rerio
ENSMUSG00000022099 Dmtn dematin actin binding protein protein_coding Mus_musculus

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