C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: C-terminal binding protein 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000159692 CTBP1 9606 - 4:1211448-1249953 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000290921 CTBP1-001 1211448-1249137 protein_coding
  ENST00000382950 CTBP1-014 1212275-1213754 retained_intron
  ENST00000382952 CTBP1-003 1211448-1249112 protein_coding
  ENST00000503594 CTBP1-015 1211685-1214462 protein_coding
  ENST00000504092 CTBP1-010 1212182-1228284 protein_coding
  ENST00000504784 CTBP1-017 1221458-1225395 protein_coding
  ENST00000505826 CTBP1-021 1214421-1231144 processed_transcript
  ENST00000506180 CTBP1-005 1216175-1249953 protein_coding
  ENST00000510568 CTBP1-008 1234687-1241923 protein_coding
  ENST00000510739 CTBP1-012 1212913-1225389 nonsense_mediated_decay
  ENST00000511907 CTBP1-011 1213991-1216407 retained_intron
  ENST00000513420 CTBP1-002 1225438-1248740 protein_coding
  ENST00000514210 CTBP1-013 1223420-1248976 protein_coding
  ENST00000514495 CTBP1-004 1225351-1249118 processed_transcript
  ENST00000514596 CTBP1-016 1211914-1213050 retained_intron
  ENST00000514669 CTBP1-020 1216086-1233224 processed_transcript
  ENST00000515399 CTBP1-006 1225360-1249931 protein_coding
  ENST00000515690 CTBP1-009 1235753-1241463 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000290921ENST00000382952ENST00000503594ENST00000504092ENST00000510568ENST00000510739ENST00000513420ENST00000514210
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000290921 22.708±0.00 N/A N/A 33.567±0.00 22.389±0.00 19.325±0.00 10.446±0.00 22.311±0.00 6.177±2.08 14.116±0.00 13.094±0.00 32.529±0.00 16.011±3.33 23.515±0.00
ENST00000382952 18.231±0.00 29.320±0.00 1.518±0.00 12.333±0.00 8.710±0.00 12.213±0.57 13.733±11.21 21.065±0.00 11.302±6.60 13.899±9.65 17.256±14.14 19.121±10.78 23.290±1.65 N/A
ENST00000503594 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 24.526±0.00 31.417±0.00 N/A
ENST00000504092 38.572±0.00 N/A N/A N/A 25.476±19.97 N/A N/A N/A N/A N/A N/A 95.283±0.00 N/A 30.521±0.00
ENST00000510568 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.057±0.00 N/A N/A N/A N/A
ENST00000510739 N/A N/A 5.361±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000513420 N/A N/A N/A 13.908±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000514210 N/A N/A N/A N/A 5.945±0.00 N/A N/A 5.542±0.00 N/A N/A N/A 32.703±0.00 35.099±0.00 35.944±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006LO CIL_0006LO_0001 CGP 4:1166932-1249953
CIL_0006LN CIL_0006LN_0001 CGP 4:1211448-1340147

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0001106 IDA RNA polymerase II transcription corepressor activity
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0004616 IEA phosphogluconate dehydrogenase (decarboxylating) activity
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005667 IEA transcription factor complex
GO:0005829 IEA cytosol
GO:0006098 IEA pentose-phosphate shunt
GO:0006351 IEA transcription, DNA-templated
GO:0006468 TAS protein phosphorylation
GO:0007030 IEA Golgi organization
GO:0008022 TAS protein C-terminus binding
GO:0008134 IPI transcription factor binding
GO:0008152 IEA metabolic process
GO:0008285 TAS negative regulation of cell proliferation
GO:0016616 IEA oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0017053 ISS transcriptional repressor complex
GO:0019079 TAS viral genome replication
GO:0019904 IPI protein domain specific binding
GO:0031065 IMP positive regulation of histone deacetylation
GO:0034401 IMP regulation of transcription by chromatin organization
GO:0035067 IMP negative regulation of histone acetylation
GO:0042803 IEA protein homodimerization activity
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0050872 ISS white fat cell differentiation
GO:0051287 ISS:IEA NAD binding
GO:0051726 IMP regulation of cell cycle
GO:0055114 IEA oxidation-reduction process
GO:0070491 IPI repressing transcription factor binding
GO:0090241 IMP negative regulation of histone H4 acetylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019213 CTBP1 C-terminal binding protein 1 protein_coding Danio_rerio
ENSMUSG00000037373 Ctbp1 C-terminal binding protein 1 protein_coding Mus_musculus

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