C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: arachidonate 15-lipoxygenase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000161905 ALOX15 9606 - 17:4630902-4642294 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000293761 ALOX15-201 4630926-4641665 protein_coding
  ENST00000570836 ALOX15-001 4630902-4642294 protein_coding
  ENST00000572265 ALOX15-005 4638927-4639882 protein_coding
  ENST00000573740 ALOX15-004 4638927-4641678 retained_intron
  ENST00000574640 ALOX15-002 4631334-4641935 protein_coding
  ENST00000576394 ALOX15-008 4639438-4641875 protein_coding
  ENST00000576572 ALOX15-006 4637170-4639164 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000293761ENST00000570836ENST00000572265ENST00000573740ENST00000574640ENST00000576572
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000293761 0.048±0.00 0.161±0.00 0.069±0.03 0.058±0.00 3.467±0.00 N/A 0.015±0.00 N/A 8.378±3.66 N/A 1.440±1.08 0.182±0.07 0.673±0.19
ENST00000570836 N/A N/A N/A N/A N/A N/A N/A 0.876±0.00 0.982±0.00 N/A 0.285±0.00 N/A N/A
ENST00000572265 N/A N/A N/A 0.755±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000573740 0.113±0.00 N/A N/A N/A N/A 1.272±0.00 N/A N/A N/A N/A N/A 0.257±0.00 N/A
ENST00000574640 N/A N/A N/A 0.102±0.00 N/A N/A N/A N/A 3.524±0.00 0.008±0.00 N/A 0.176±0.00 N/A
ENST00000576572 0.121±0.00 N/A N/A 0.157±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001RX CIL_0001RX_0001 CGP 17:4630902-4704337

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001503 ISS ossification
GO:0002820 ISS negative regulation of adaptive immune response
GO:0004052 IDA arachidonate 12-lipoxygenase activity
GO:0005506 IEA:ISS iron ion binding
GO:0005515 IPI:IEA protein binding
GO:0005546 IDA phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 IEA cytoplasm
GO:0005811 IDA lipid particle
GO:0005829 ISS cytosol
GO:0005886 ISS plasma membrane
GO:0006646 ISS phosphatidylethanolamine biosynthetic process
GO:0006691 TAS leukotriene metabolic process
GO:0006954 TAS inflammatory response
GO:0010811 IDA positive regulation of cell-substrate adhesion
GO:0016020 IDA membrane
GO:0016702 IEA oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0019369 IDA arachidonic acid metabolic process
GO:0019372 IDA lipoxygenase pathway
GO:0030282 ISS bone mineralization
GO:0030838 ISS positive regulation of actin filament polymerization
GO:0031234 IDA extrinsic component of cytoplasmic side of plasma membrane
GO:0034116 IEA positive regulation of heterotypic cell-cell adhesion
GO:0034976 ISS response to endoplasmic reticulum stress
GO:0035358 ISS regulation of peroxisome proliferator activated receptor signaling pathway
GO:0035963 IMP cellular response to interleukin-13
GO:0042060 ISS wound healing
GO:0043277 ISS apoptotic cell clearance
GO:0044281 TAS small molecule metabolic process
GO:0046872 IEA metal ion binding
GO:0047977 IEA hepoxilin-epoxide hydrolase activity
GO:0050473 IDA arachidonate 15-lipoxygenase activity
GO:0051120 IEA hepoxilin A3 synthase activity
GO:0051122 ISS hepoxilin biosynthetic process
GO:0055114 IEA oxidation-reduction process
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:0071277 IDA cellular response to calcium ion
GO:0097260 TAS eoxin A4 synthase activity
GO:1901074 ISS regulation of engulfment of apoptotic cell
GO:2001303 ISS lipoxin A4 biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000069463 alox12 arachidonate 12-lipoxygenase protein_coding Danio_rerio
ENSMUSG00000018924 Alox15 arachidonate 15-lipoxygenase protein_coding Mus_musculus

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