C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: arachidonate 15-lipoxygenase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000018924 Alox15 10090 - 11:70344152-70352031 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000019068 Alox15-001 70344152-70352031 protein_coding
  ENSMUST00000130000 Alox15-002 70344605-70345696 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000019068ENSMUST00000130000
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000019068 12.784±8.46 0.476±0.27 0.476±0.08 0.016±0.00 1.720±0.64 0.461±0.25 0.576±0.17 0.205±0.11 0.833±0.94 4.427±1.69 0.044±0.03 15.638±7.44 0.041±0.02 0.256±0.04
ENSMUST00000130000 N/A 0.872±0.39 N/A 0.087±0.00 2.472±0.09 0.930±0.28 N/A N/A N/A N/A 0.179±0.00 N/A 0.163±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001RX CIL_0001RX_0002 CGP 11:70344152-70410031

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001503 IMP ossification
GO:0002820 IMP negative regulation of adaptive immune response
GO:0004052 IDA arachidonate 12-lipoxygenase activity
GO:0005506 ISS iron ion binding
GO:0005546 ISS phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 IDA cytoplasm
GO:0005811 ISS lipid particle
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0006646 IMP phosphatidylethanolamine biosynthetic process
GO:0010811 ISS positive regulation of cell-substrate adhesion
GO:0016020 ISS membrane
GO:0019369 IDA arachidonic acid metabolic process
GO:0019372 IDA lipoxygenase pathway
GO:0030282 IMP bone mineralization
GO:0030838 IMP positive regulation of actin filament polymerization
GO:0031234 ISS extrinsic component of cytoplasmic side of plasma membrane
GO:0034116 IEA positive regulation of heterotypic cell-cell adhesion
GO:0034976 IMP response to endoplasmic reticulum stress
GO:0035358 IMP regulation of peroxisome proliferator activated receptor signaling pathway
GO:0035963 ISS cellular response to interleukin-13
GO:0042060 IMP wound healing
GO:0043277 IMP apoptotic cell clearance
GO:0047977 IEA hepoxilin-epoxide hydrolase activity
GO:0050473 IDA arachidonate 15-lipoxygenase activity
GO:0051120 IEA hepoxilin A3 synthase activity
GO:0051122 ISS hepoxilin biosynthetic process
GO:0055114 IEA oxidation-reduction process
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:0071277 ISS cellular response to calcium ion
GO:1901074 IMP regulation of engulfment of apoptotic cell
GO:2001303 IMP lipoxin A4 biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000069463 alox12 arachidonate 12-lipoxygenase protein_coding Danio_rerio
ENSG00000161905 ALOX15 arachidonate 15-lipoxygenase protein_coding Homo_sapiens

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