C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: actin related protein 2/3 complex, subunit 2, 34kDa
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000163466 ARPC2 9606 + 2:218217094-218254356 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000295685 ARPC2-001 218217210-218254356 protein_coding
  ENST00000315717 ARPC2-002 218217094-218254348 protein_coding
  ENST00000414983 ARPC2-007 218217202-218239485 nonsense_mediated_decay
  ENST00000420104 ARPC2-016 218217141-218234398 protein_coding
  ENST00000420201 ARPC2-010 218217181-218238849 nonsense_mediated_decay
  ENST00000456575 ARPC2-015 218245426-218254123 protein_coding
  ENST00000462034 ARPC2-013 218238719-218239562 processed_transcript
  ENST00000465395 ARPC2-012 218217455-218239195 retained_intron
  ENST00000470146 ARPC2-003 218233000-218254108 retained_intron
  ENST00000471355 ARPC2-008 218225919-218229303 retained_intron
  ENST00000472753 ARPC2-018 218225919-218239017 retained_intron
  ENST00000477992 ARPC2-004 218235341-218254108 processed_transcript
  ENST00000478612 ARPC2-005 218217194-218245457 processed_transcript
  ENST00000480062 ARPC2-006 218217197-218238723 processed_transcript
  ENST00000484961 ARPC2-009 218228803-218238730 processed_transcript
  ENST00000487321 ARPC2-014 218249592-218254110 processed_transcript
  ENST00000489598 ARPC2-011 218217147-218235052 retained_intron
  ENST00000491780 ARPC2-017 218217149-218235390 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000295685ENST00000315717ENST00000456575ENST00000470146ENST00000477992ENST00000489598
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000295685 N/A N/A 4.734±0.00 5.825±0.00 N/A N/A N/A N/A N/A N/A N/A 35.842±0.00 95.530±0.00 57.043±0.00
ENST00000315717 87.259±0.00 127.945±0.00 N/A 14.708±0.00 59.620±36.63 55.963±39.56 32.711±23.64 37.336±26.22 28.826±4.26 65.060±52.19 41.118±27.66 86.286±46.00 217.112±95.17 72.744±55.28
ENST00000456575 N/A N/A N/A N/A N/A N/A 24.463±0.00 N/A 20.909±0.00 131.905±0.00 35.785±0.00 N/A N/A N/A
ENST00000470146 N/A N/A 1.895±0.00 N/A N/A N/A N/A N/A 4.103±0.00 4.463±0.00 N/A 5.018±0.00 N/A N/A
ENST00000477992 N/A 19.388±0.00 N/A N/A 4.159±0.00 5.773±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000489598 N/A N/A N/A N/A N/A N/A N/A N/A N/A 8.971±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007WL CIL_0007WL_0001 VISTA 2:217636448-218238840
CIL_0005VM CIL_0005VM_0001 CGP 2:218162845-218254356
CIL_0005VL CIL_0005VL_0001 CGP 2:218217094-218263859

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005200 IDA structural constituent of cytoskeleton
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005768 IEA endosome
GO:0005794 IDA Golgi apparatus
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0005885 IDA:IEA Arp2/3 protein complex
GO:0005886 IEA plasma membrane
GO:0005925 IDA focal adhesion
GO:0006928 TAS cellular component movement
GO:0010592 IMP positive regulation of lamellipodium assembly
GO:0015629 TAS:IEA actin cytoskeleton
GO:0019894 IEA kinesin binding
GO:0030833 IEA regulation of actin filament polymerization
GO:0030838 IEA positive regulation of actin filament polymerization
GO:0031252 IEA cell leading edge
GO:0034314 IDA:IEA Arp2/3 complex-mediated actin nucleation
GO:0035650 IEA AP-1 adaptor complex binding
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043005 IEA neuron projection
GO:0045087 TAS innate immune response
GO:0045202 IEA synapse
GO:0051015 IDA actin filament binding
GO:0070062 IDA extracellular vesicular exosome
GO:0071933 IEA Arp2/3 complex binding
GO:1900026 IEA positive regulation of substrate adhesion-dependent cell spreading

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075989 arpc2 actin related protein 2/3 complex, subunit 2 protein_coding Danio_rerio
ENSMUSG00000006304 Arpc2 actin related protein 2/3 complex, subunit 2 protein_coding Mus_musculus

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