C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glutamate receptor, metabotropic 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000164082 GRM2 9606 + 3:51707070-51718613 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000296479 GRM2-002 51707088-51718112 nonsense_mediated_decay
  ENST00000395052 GRM2-001 51707070-51718410 protein_coding
  ENST00000419928 GRM2-007 51707411-51709193 protein_coding
  ENST00000442933 GRM2-005 51708845-51718252 protein_coding
  ENST00000464585 GRM2-004 51707305-51718613 retained_intron
  ENST00000475478 GRM2-003 51707090-51718613 processed_transcript
  ENST00000477330 GRM2-008 51711272-51712581 processed_transcript
  ENST00000496661 GRM2-006 51711272-51714068 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastHeartKidneyLungMuscleOvaryTestisENST00000395052ENST00000419928ENST00000442933ENST00000464585ENST00000475478ENST00000477330ENST00000496661
Transcript ID Adipose Adrenal Bladder Brain Breast Heart Kidney Lung Muscle Ovary Testis
ENST00000395052 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.117±0.02 N/A
ENST00000419928 0.109±0.00 N/A N/A N/A N/A N/A 0.104±0.00 N/A N/A N/A N/A
ENST00000442933 0.022±0.00 0.462±0.00 N/A 1.012±0.00 0.111±0.00 0.050±0.00 N/A N/A N/A N/A N/A
ENST00000464585 0.008±0.00 0.262±0.00 0.046±0.00 0.191±0.04 0.060±0.00 N/A 0.005±0.00 0.017±0.00 0.003±0.00 0.087±0.01 0.509±0.32
ENST00000475478 0.055±0.00 0.366±0.00 N/A 0.618±0.00 N/A N/A N/A N/A N/A 0.124±0.02 0.635±0.00
ENST00000477330 N/A N/A N/A N/A N/A 0.872±0.00 0.255±0.00 N/A N/A N/A N/A
ENST00000496661 N/A N/A N/A N/A N/A N/A 0.031±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003FF CIL_0003FF_0002 CGP 3:51662693-51718613
CIL_00087C CIL_00087C_0001 VISTA 3:51705330-52307529

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001641 IBA group II metabotropic glutamate receptor activity
GO:0004930 IEA G-protein coupled receptor activity
GO:0005246 IBA calcium channel regulator activity
GO:0005515 IEA protein binding
GO:0005622 IEA intracellular
GO:0005886 TAS plasma membrane
GO:0005887 IBA integral component of plasma membrane
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007194 TAS negative regulation of adenylate cyclase activity
GO:0007196 IBA adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007268 TAS synaptic transmission
GO:0008066 TAS glutamate receptor activity
GO:0014047 IEA glutamate secretion
GO:0016021 IEA integral component of membrane
GO:0030054 IEA cell junction
GO:0030424 IEA axon
GO:0042734 IBA presynaptic membrane
GO:0043005 IEA neuron projection
GO:0051966 IBA regulation of synaptic transmission, glutamatergic

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004150 grm2a glutamate receptor, metabotropic 2a protein_coding Danio_rerio
ENSDARG00000007195 GRM2 (2 of 2) glutamate receptor, metabotropic 2 protein_coding Danio_rerio
ENSMUSG00000023192 Grm2 glutamate receptor, metabotropic 2 protein_coding Mus_musculus

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