C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: WNK lysine deficient protein kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000165238 WNK2 9606 + 9:93184916-93320572 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000297954 WNK2-001 93184930-93318271 protein_coding
  ENST00000395477 WNK2-201 93184930-93320572 protein_coding
  ENST00000411624 WNK2-010 93234923-93319208 protein_coding
  ENST00000427277 WNK2-202 93184930-93319373 protein_coding
  ENST00000432730 WNK2-009 93184943-93319204 protein_coding
  ENST00000448039 WNK2-011 93184916-93259075 protein_coding
  ENST00000448251 WNK2-002 93263948-93320572 protein_coding
  ENST00000453718 WNK2-014 93289187-93308584 protein_coding
  ENST00000460335 WNK2-004 93308501-93309195 processed_transcript
  ENST00000462595 WNK2-005 93267020-93267815 processed_transcript
  ENST00000464625 WNK2-012 93256726-93259251 processed_transcript
  ENST00000467401 WNK2-008 93306637-93320564 retained_intron
  ENST00000471076 WNK2-003 93315488-93320566 processed_transcript
  ENST00000474009 WNK2-007 93293089-93308588 processed_transcript
  ENST00000478583 WNK2-013 93263266-93268040 processed_transcript
  ENST00000479696 WNK2-006 93293133-93300326 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000297954ENST00000395477ENST00000411624ENST00000427277ENST00000432730ENST00000448039ENST00000448251ENST00000453718ENST00000467401ENST00000471076ENST00000474009ENST00000479696
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000297954 N/A N/A N/A N/A N/A N/A 7.883±0.00 N/A N/A N/A N/A 5.241±0.00 0.844±0.00 2.489±0.00
ENST00000395477 N/A 3.768±0.00 N/A N/A 1.362±0.84 3.922±2.70 11.702±10.67 N/A 0.327±0.22 0.558±0.00 11.136±0.00 2.397±1.31 0.957±0.36 5.788±0.00
ENST00000411624 N/A N/A N/A 5.283±0.00 N/A N/A N/A 0.175±0.00 0.093±0.00 0.219±0.00 N/A 1.675±1.23 0.653±0.25 2.564±0.17
ENST00000427277 N/A N/A N/A N/A N/A 2.838±0.00 N/A N/A N/A N/A 0.562±0.00 N/A N/A N/A
ENST00000432730 0.111±0.00 N/A N/A 7.740±0.00 0.961±0.00 N/A 7.775±0.00 N/A N/A N/A 3.226±0.00 N/A 0.542±0.00 N/A
ENST00000448039 0.490±0.00 N/A 0.115±0.00 2.760±0.00 2.558±0.00 N/A 4.323±0.00 0.341±0.05 2.337±0.00 0.112±0.00 5.549±0.00 2.860±0.00 N/A N/A
ENST00000448251 0.378±0.00 N/A N/A N/A 3.083±0.00 11.724±0.00 N/A N/A N/A 0.556±0.00 2.141±0.00 N/A N/A 6.416±0.00
ENST00000453718 N/A N/A N/A N/A N/A N/A N/A 0.576±0.00 N/A N/A N/A 4.432±3.43 3.335±0.00 4.992±0.00
ENST00000467401 N/A N/A N/A N/A N/A N/A N/A N/A 0.093±0.00 N/A N/A 2.201±0.00 N/A N/A
ENST00000471076 N/A N/A N/A N/A 1.114±0.09 4.866±0.00 N/A N/A N/A N/A N/A 1.067±0.00 N/A N/A
ENST00000474009 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 15.149±0.00 7.160±0.00 N/A
ENST00000479696 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.843±0.00 N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004674 ISS:IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005524 ISS:IEA ATP binding
GO:0005737 IDA cytoplasm
GO:0005886 IEA plasma membrane
GO:0006468 IDA:IEA protein phosphorylation
GO:0008285 IMP negative regulation of cell proliferation
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0035556 ISS intracellular signal transduction
GO:0046777 IDA protein autophosphorylation
GO:0070373 IMP negative regulation of ERK1 and ERK2 cascade
GO:2000021 IMP regulation of ion homeostasis
GO:2000651 IMP positive regulation of sodium ion transmembrane transporter activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000037989 Wnk2 WNK lysine deficient protein kinase 2 protein_coding Mus_musculus

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