C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: WNK lysine deficient protein kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000037989 Wnk2 10090 - 13:49036303-49148014 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000035538 Wnk2-201 49036303-49148014 protein_coding
  ENSMUST00000049265 Wnk2-202 49036303-49148014 protein_coding
  ENSMUST00000091623 Wnk2-203 49038874-49148014 protein_coding
  ENSMUST00000110096 Wnk2-204 49037981-49148014 protein_coding
  ENSMUST00000110097 Wnk2-205 49036303-49148014 protein_coding
  ENSMUST00000159196 Wnk2-004 49037609-49060883 protein_coding
  ENSMUST00000159559 Wnk2-005 49036310-49147232 protein_coding
  ENSMUST00000159633 Wnk2-006 49061329-49071015 nonsense_mediated_decay
  ENSMUST00000160087 Wnk2-003 49037620-49078063 protein_coding
  ENSMUST00000162403 Wnk2-002 49036309-49147232 protein_coding
  ENSMUST00000162581 Wnk2-001 49036303-49148012 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000035538ENSMUST00000049265ENSMUST00000091623ENSMUST00000110096ENSMUST00000110097ENSMUST00000159196ENSMUST00000159559ENSMUST00000159633ENSMUST00000160087ENSMUST00000162403ENSMUST00000162581
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000035538 N/A 0.236±0.09 N/A N/A N/A 0.865±0.00 N/A 0.092±0.01 0.011±0.00 N/A N/A 0.619±0.00 N/A 0.045±0.01
ENSMUST00000049265 N/A 0.427±0.21 1.107±0.00 N/A 0.499±0.11 1.573±0.44 N/A 0.117±0.05 0.031±0.00 0.255±0.13 N/A 1.263±0.59 1.159±0.45 N/A
ENSMUST00000091623 N/A 0.155±0.00 N/A N/A N/A N/A N/A N/A 0.021±0.02 N/A N/A N/A N/A N/A
ENSMUST00000110096 N/A N/A N/A N/A 0.217±0.00 1.297±0.30 N/A 0.153±0.00 0.017±0.00 N/A N/A 0.990±0.24 N/A 0.035±0.00
ENSMUST00000110097 N/A N/A 4.362±0.00 10.189±0.00 0.729±0.00 0.912±0.00 3.542±1.36 0.126±0.00 N/A 0.474±0.11 17.557±2.79 N/A N/A 0.083±0.04
ENSMUST00000159196 0.823±0.68 0.515±0.05 3.936±0.65 10.612±2.67 0.702±0.33 2.106±0.51 3.256±0.98 N/A 0.044±0.03 0.175±0.00 7.822±1.94 1.465±0.38 0.942±0.36 0.035±0.00
ENSMUST00000159559 N/A N/A N/A 16.108±0.00 0.505±0.00 N/A 1.050±0.00 N/A 0.033±0.00 N/A 4.428±1.25 N/A N/A 0.145±0.00
ENSMUST00000159633 N/A N/A N/A N/A 1.074±0.00 N/A N/A N/A 0.132±0.00 N/A N/A N/A N/A 0.401±0.00
ENSMUST00000160087 0.346±0.34 0.257±0.03 1.905±0.00 N/A N/A 1.101±0.00 N/A 0.243±0.06 0.041±0.02 0.289±0.00 N/A N/A N/A N/A
ENSMUST00000162403 0.820±0.73 0.254±0.07 N/A 23.555±0.00 0.331±0.10 1.128±0.13 N/A 0.138±0.06 0.028±0.02 0.132±0.00 N/A 1.358±0.77 2.467±2.56 0.118±0.07
ENSMUST00000162581 N/A 0.284±0.08 N/A N/A N/A 0.593±0.00 N/A 0.114±0.02 0.014±0.00 N/A N/A 1.309±1.04 0.580±0.30 0.049±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008QG CIL_0008QG_0002 VISTA 13:48479624-49081302

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003674 ND molecular_function
GO:0004674 IEA protein serine/threonine kinase activity
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0005886 IEA plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0008285 IEA negative regulation of cell proliferation
GO:0046777 IEA protein autophosphorylation
GO:0070373 IEA negative regulation of ERK1 and ERK2 cascade
GO:2000021 IEA regulation of ion homeostasis
GO:2000651 IEA positive regulation of sodium ion transmembrane transporter activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000165238 WNK2 WNK lysine deficient protein kinase 2 protein_coding Homo_sapiens

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