C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info

Description: WNK lysine deficient protein kinase 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000297954 WNK2-001 ENSG00000165238 9606 + 9:93184930-93318271 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; HeartOvaryPlacentaTestisENST00000297954
Transcript ID Heart Ovary Placenta Testis
ENST00000297954 7.883±0.00 5.241±0.00 0.844±0.00 2.489±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004674 ISS:IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005524 ISS:IEA ATP binding
GO:0005737 IDA cytoplasm
GO:0005886 IEA plasma membrane
GO:0006468 IDA:IEA protein phosphorylation
GO:0008285 IMP negative regulation of cell proliferation
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0035556 ISS intracellular signal transduction
GO:0046777 IDA protein autophosphorylation
GO:0070373 IMP negative regulation of ERK1 and ERK2 cascade
GO:2000021 IMP regulation of ion homeostasis
GO:2000651 IMP positive regulation of sodium ion transmembrane transporter activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000035538 Wnk2-201 protein_coding Mus_musculus 0 2815
ENSMUST00000110096 Wnk2-204 protein_coding Mus_musculus 0 2815
ENSMUST00000049265 Wnk2-202 protein_coding Mus_musculus 0 2815
ENSMUST00000091623 Wnk2-203 protein_coding Mus_musculus 0 2815
ENSMUST00000110097 Wnk2-205 protein_coding Mus_musculus 0 2815
ENSMUST00000162581 Wnk2-001 protein_coding Mus_musculus 0 2815
ENSMUST00000159559 Wnk2-005 protein_coding Mus_musculus 0 2305
ENSMUST00000162403 Wnk2-002 protein_coding Mus_musculus 0 2305
ENSMUST00000160087 Wnk2-003 protein_coding Mus_musculus 0 1415
ENSMUST00000159196 Wnk2-004 protein_coding Mus_musculus 0 1415
ENSDART00000113584 CABZ01066573.1-201 protein_coding Danio_rerio 0 593
ENSMUST00000159633 Wnk2-006 nonsense_mediated_decay Mus_musculus 0 383

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