C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Werner syndrome, RecQ helicase-like
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000165392 WRN 9606 + 8:31033801-31173769 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000298139 WRN-001 31033801-31173769 protein_coding
  ENST00000520169 WRN-003 31119956-31124965 retained_intron
  ENST00000521620 WRN-002 31087644-31173763 retained_intron

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000298139ENST00000521620
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000298139 0.744±0.00 1.240±0.00 0.304±0.00 1.021±0.26 2.097±1.04 0.875±0.00 0.406±0.00 0.544±0.00 1.153±0.91 0.265±0.00 0.190±0.03 1.337±0.55 1.237±0.91 4.200±1.59
ENST00000521620 0.534±0.00 0.795±0.00 N/A N/A N/A N/A 0.259±0.00 N/A 0.309±0.00 0.262±0.00 N/A 0.523±0.05 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000166 IEA nucleotide binding
GO:0000287 IDA magnesium ion binding
GO:0000403 IDA Y-form DNA binding
GO:0000405 IDA bubble DNA binding
GO:0000723 IMP telomere maintenance
GO:0000731 IDA DNA synthesis involved in DNA repair
GO:0001302 IEA replicative cell aging
GO:0003676 IEA nucleic acid binding
GO:0003677 IDA DNA binding
GO:0003678 IMP DNA helicase activity
GO:0003824 IEA catalytic activity
GO:0004003 IDA ATP-dependent DNA helicase activity
GO:0004386 IDA helicase activity
GO:0004527 IDA exonuclease activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005622 IEA intracellular
GO:0005634 IEA nucleus
GO:0005654 IDA nucleoplasm
GO:0005730 IDA nucleolus
GO:0005813 IDA centrosome
GO:0006139 IEA nucleobase-containing compound metabolic process
GO:0006200 IEA ATP catabolic process
GO:0006259 IDA DNA metabolic process
GO:0006260 IMP:IEA DNA replication
GO:0006281 IEA DNA repair
GO:0006284 IDA base-excision repair
GO:0006302 IMP double-strand break repair
GO:0006310 IEA DNA recombination
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0006979 IDA response to oxidative stress
GO:0007568 NAS aging
GO:0007569 IMP cell aging
GO:0008026 IEA ATP-dependent helicase activity
GO:0008408 IDA:IEA 3'-5' exonuclease activity
GO:0009267 IDA cellular response to starvation
GO:0009378 IDA four-way junction helicase activity
GO:0010225 IDA response to UV-C
GO:0010259 IMP multicellular organismal aging
GO:0016887 IDA ATPase activity
GO:0030145 IDA manganese ion binding
GO:0031297 IMP replication fork processing
GO:0032066 IDA nucleolus to nucleoplasm transport
GO:0032389 IDA MutLalpha complex
GO:0032403 IDA protein complex binding
GO:0032508 IEA DNA duplex unwinding
GO:0040009 IEA regulation of growth rate
GO:0042803 IDA protein homodimerization activity
GO:0042981 IGI regulation of apoptotic process
GO:0043138 IDA 3'-5' DNA helicase activity
GO:0043140 IEA ATP-dependent 3'-5' DNA helicase activity
GO:0044237 IEA cellular metabolic process
GO:0051345 IDA positive regulation of hydrolase activity
GO:0051880 IDA G-quadruplex DNA binding
GO:0071480 IDA cellular response to gamma radiation
GO:0090305 IEA nucleic acid phosphodiester bond hydrolysis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000053065 wrn Werner syndrome protein_coding Danio_rerio
ENSMUSG00000031583 Wrn Werner syndrome homolog (human) protein_coding Mus_musculus

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