C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Werner syndrome homolog (human)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031583 Wrn 10090 - 8:33234384-33385527 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000033990 Wrn-201 33234384-33385527 protein_coding
  ENSMUST00000033991 Wrn-202 33234384-33385527 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000033990ENSMUST00000033991
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000033990 1.498±0.36 N/A 1.177±0.32 0.903±0.00 1.140±0.38 0.962±0.05 0.457±0.04 0.962±0.25 1.989±1.71 0.882±0.29 0.312±0.04 1.177±0.46 1.167±0.20 2.144±0.91
ENSMUST00000033991 0.371±0.05 0.871±0.20 1.573±0.34 1.012±0.52 0.959±0.35 0.735±0.65 N/A 0.684±0.24 1.234±0.76 0.345±0.11 0.247±0.12 1.339±0.75 1.718±0.80 1.313±0.43

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006KM CIL_0006KM_0002 CGP 8:31818028-33385527
CIL_0006KJ CIL_0006KJ_0002 CGP 8:33234384-33417468

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 ISS magnesium ion binding
GO:0000403 IEA Y-form DNA binding
GO:0000405 IEA bubble DNA binding
GO:0000723 IMP telomere maintenance
GO:0000731 IEA DNA synthesis involved in DNA repair
GO:0001302 IMP replicative cell aging
GO:0003677 IEA DNA binding
GO:0003678 IEA DNA helicase activity
GO:0004003 IEA ATP-dependent DNA helicase activity
GO:0004386 IEA helicase activity
GO:0004527 IEA exonuclease activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 IDA nucleoplasm
GO:0005730 ISO nucleolus
GO:0005813 IEA centrosome
GO:0006200 IEA ATP catabolic process
GO:0006259 ISS DNA metabolic process
GO:0006260 IMP DNA replication
GO:0006284 IEA base-excision repair
GO:0006302 ISS double-strand break repair
GO:0006310 IEA DNA recombination
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0006979 IEA response to oxidative stress
GO:0007569 IEA cell aging
GO:0008408 ISS 3'-5' exonuclease activity
GO:0009267 ISO cellular response to starvation
GO:0009378 IEA four-way junction helicase activity
GO:0010225 IEA response to UV-C
GO:0010259 IGI multicellular organismal aging
GO:0016887 IEA ATPase activity
GO:0030145 ISS manganese ion binding
GO:0031297 IEA replication fork processing
GO:0032066 ISO nucleolus to nucleoplasm transport
GO:0032389 IEA MutLalpha complex
GO:0032403 IEA protein complex binding
GO:0032508 IEA DNA duplex unwinding
GO:0040009 IMP regulation of growth rate
GO:0042803 IEA protein homodimerization activity
GO:0042981 IEA regulation of apoptotic process
GO:0043138 IEA 3'-5' DNA helicase activity
GO:0043140 IEA ATP-dependent 3'-5' DNA helicase activity
GO:0051345 IEA positive regulation of hydrolase activity
GO:0051880 IEA G-quadruplex DNA binding
GO:0071480 ISS cellular response to gamma radiation
GO:0090305 IEA nucleic acid phosphodiester bond hydrolysis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000053065 wrn Werner syndrome protein_coding Danio_rerio
ENSG00000165392 WRN Werner syndrome, RecQ helicase-like protein_coding Homo_sapiens

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