C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ret proto-oncogene
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000165731 RET 9606 + 10:43077027-43130351 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000340058 RET-002 43077079-43127504 protein_coding
  ENST00000355710 RET-001 43077027-43130351 protein_coding
  ENST00000479913 RET-004 43104732-43106490 retained_intron
  ENST00000498820 RET-003 43077074-43114593 protein_coding
  ENST00000615310 RET-201 43077069-43130345 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000340058ENST00000355710ENST00000615310
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000340058 0.039±0.00 N/A N/A 0.408±0.19 0.146±0.06 0.553±0.45 0.130±0.07 0.054±0.00 0.801±0.61 N/A 0.060±0.00 0.184±0.02 0.393±0.16 0.803±0.00
ENST00000355710 N/A 0.097±0.00 0.139±0.00 N/A 0.077±0.00 0.095±0.00 N/A N/A N/A 0.046±0.00 N/A N/A 0.231±0.00 0.134±0.01
ENST00000615310 0.052±0.00 0.088±0.00 0.106±0.00 0.878±0.00 0.199±0.00 0.266±0.13 N/A 0.059±0.00 0.136±0.00 0.059±0.00 0.118±0.00 0.131±0.04 0.260±0.14 0.337±0.13

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0001657 IEA ureteric bud development
GO:0001755 IEA neural crest cell migration
GO:0001838 IEA embryonic epithelial tube formation
GO:0004672 IEA protein kinase activity
GO:0004713 TAS:IEA protein tyrosine kinase activity
GO:0004714 IEA transmembrane receptor protein tyrosine kinase activity
GO:0004872 TAS receptor activity
GO:0005509 IDA:IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005887 IDA integral component of plasma membrane
GO:0006468 TAS:IEA protein phosphorylation
GO:0006919 IMP activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007156 IEA homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007158 IMP neuron cell-cell adhesion
GO:0007165 TAS signal transduction
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399 IEA nervous system development
GO:0007497 TAS posterior midgut development
GO:0010008 IDA endosome membrane
GO:0010976 IMP positive regulation of neuron projection development
GO:0014042 IEA positive regulation of neuron maturation
GO:0016020 IEA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030155 IDA regulation of cell adhesion
GO:0030182 IEA neuron differentiation
GO:0030335 IDA positive regulation of cell migration
GO:0033619 IDA membrane protein proteolysis
GO:0033630 IDA positive regulation of cell adhesion mediated by integrin
GO:0035799 IEA ureter maturation
GO:0042493 IEA response to drug
GO:0042551 IEA neuron maturation
GO:0043235 IDA receptor complex
GO:0045121 IEA membrane raft
GO:0045793 IEA positive regulation of cell size
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0048265 ISS response to pain
GO:0048484 IEA enteric nervous system development
GO:0050770 IEA regulation of axonogenesis
GO:0060041 IEA retina development in camera-type eye
GO:0060384 IEA innervation
GO:0061146 ISS Peyer's patch morphogenesis
GO:0071300 IMP cellular response to retinoic acid
GO:0072300 ISS positive regulation of metanephric glomerulus development
GO:0097021 ISS lymphocyte migration into lymphoid organs
GO:2001241 IMP positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000055305 ret ret proto-oncogene receptor tyrosine kinase protein_coding Danio_rerio
ENSMUSG00000030110 Ret ret proto-oncogene protein_coding Mus_musculus

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