C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: melanocortin 4 receptor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000166603 MC4R 9606 - 18:60371110-60372775 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000299766 MC4R-001 60371110-60372775 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainKidneyLiverOvaryTestisENST00000299766
Transcript ID Adrenal Brain Kidney Liver Ovary Testis
ENST00000299766 0.127±0.00 0.785±0.16 0.140±0.00 0.026±0.00 0.028±0.01 0.070±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007FH CIL_0007FH_0001 CGP 18:59899948-60372775

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002024 IEA diet induced thermogenesis
GO:0004930 IEA G-protein coupled receptor activity
GO:0004977 TAS melanocortin receptor activity
GO:0004980 IDA melanocyte-stimulating hormone receptor activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005886 TAS plasma membrane
GO:0006112 IEA energy reserve metabolic process
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007188 TAS adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007631 IEA feeding behavior
GO:0016021 IEA integral component of membrane
GO:0017046 IEA peptide hormone binding
GO:0019222 IEA regulation of metabolic process
GO:0030073 IEA insulin secretion
GO:0030819 IDA positive regulation of cAMP biosynthetic process
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032868 IEA response to insulin
GO:0042923 IPI neuropeptide binding
GO:0045780 IMP positive regulation of bone resorption
GO:0060259 IEA regulation of feeding behavior
GO:2000252 IEA negative regulation of feeding behavior
GO:2000821 IEA regulation of grooming behavior

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000015515 mc4r melanocortin 4 receptor protein_coding Danio_rerio
ENSMUSG00000047259 Mc4r melanocortin 4 receptor protein_coding Mus_musculus

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