C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000166913 YWHAB 9606 + 20:44885676-44908532 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000353703 YWHAB-002 44885676-44908532 protein_coding
  ENST00000372839 YWHAB-001 44885711-44908532 protein_coding
  ENST00000428262 YWHAB-004 44885740-44901833 protein_coding
  ENST00000445830 YWHAB-003 44885752-44901756 protein_coding
  ENST00000477896 YWHAB-006 44903819-44905079 processed_transcript
  ENST00000479421 YWHAB-005 44885702-44906520 processed_transcript
  ENST00000479758 YWHAB-007 44905591-44906520 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000353703ENST00000372839ENST00000479421
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000353703 95.409±0.00 69.070±0.00 7.053±0.00 88.865±42.13 46.688±19.31 39.016±19.08 19.343±14.30 51.276±42.54 19.424±3.94 40.751±16.31 26.229±0.00 38.541±16.99 69.001±10.11 28.581±24.51
ENST00000372839 N/A N/A 6.674±0.00 N/A 4.602±0.00 6.533±2.25 4.597±1.58 3.309±0.00 5.003±2.38 3.842±0.00 3.579±0.67 27.563±24.19 40.582±28.93 16.342±3.91
ENST00000479421 N/A N/A N/A N/A N/A 11.551±0.00 N/A N/A N/A N/A 6.202±0.00 76.880±0.00 104.441±0.00 32.947±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006IP CIL_0006IP_0002 CGP 20:44751808-44908532
CIL_0003UV CIL_0003UV_0001 CGP 20:44885676-44959035

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 TAS MAPK cascade
GO:0000186 TAS activation of MAPKK activity
GO:0003714 IEA transcription corepressor activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005925 IDA focal adhesion
GO:0006605 IEA protein targeting
GO:0006915 TAS apoptotic process
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007265 TAS Ras protein signal transduction
GO:0007411 TAS axon guidance
GO:0008022 IEA protein C-terminus binding
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0010467 TAS gene expression
GO:0016020 IDA membrane
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0017053 IEA transcriptional repressor complex
GO:0019899 IPI enzyme binding
GO:0019904 IPI:IEA protein domain specific binding
GO:0030659 TAS cytoplasmic vesicle membrane
GO:0032403 IEA protein complex binding
GO:0035308 IDA negative regulation of protein dephosphorylation
GO:0035329 TAS hippo signaling
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042826 IPI histone deacetylase binding
GO:0043085 IDA positive regulation of catalytic activity
GO:0043234 IEA protein complex
GO:0045087 TAS innate immune response
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050815 IPI phosphoserine binding
GO:0051219 IPI phosphoprotein binding
GO:0051220 IDA cytoplasmic sequestering of protein
GO:0051291 IEA protein heterooligomerization
GO:0061024 TAS membrane organization
GO:0070062 IDA extracellular vesicular exosome
GO:0097193 TAS intrinsic apoptotic signaling pathway
GO:1900740 TAS positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013078 ywhaba tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a protein_coding Danio_rerio
ENSDARG00000075758 ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b protein_coding Danio_rerio
ENSMUSG00000018326 Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide protein_coding Mus_musculus

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