C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: gremlin 1, DAN family BMP antagonist
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000166923 GREM1 9606 + 15:32717974-32745107 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000560677 GREM1-005 32718004-32731275 protein_coding
  ENST00000560830 GREM1-002 32718004-32733302 protein_coding
  ENST00000622074 GREM1-001 32717974-32745107 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000560677ENST00000560830ENST00000622074
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000560677 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.483±1.16 N/A N/A N/A
ENST00000560830 13.262±0.00 14.416±0.00 0.959±0.00 4.028±2.37 17.026±16.48 30.153±25.95 0.105±0.08 1.021±0.86 0.958±0.32 0.753±0.36 1.099±0.00 8.335±6.17 0.206±0.04 0.881±0.48
ENST00000622074 1.531±0.00 3.238±0.00 0.028±0.00 0.676±0.56 1.558±1.38 5.048±4.71 0.020±0.02 0.209±0.19 0.119±0.04 0.099±0.07 0.020±0.00 0.852±0.53 0.037±0.02 0.159±0.12

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00097N CIL_00097N_0001 VISTA 15:32499326-33100458
CIL_0005IJ CIL_0005IJ_0002 CGP 15:32641676-32745107

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000902 IDA cell morphogenesis
GO:0001525 IEA angiogenesis
GO:0001658 IEA branching involved in ureteric bud morphogenesis
GO:0002042 ISS cell migration involved in sprouting angiogenesis
GO:0002092 ISS positive regulation of receptor internalization
GO:0002689 IEA negative regulation of leukocyte chemotaxis
GO:0003257 ISS positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003337 IEA mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0005125 IEA cytokine activity
GO:0005515 IPI protein binding
GO:0005615 NAS extracellular space
GO:0006915 IEA apoptotic process
GO:0007165 ISS signal transduction
GO:0007171 ISS activation of transmembrane receptor protein tyrosine kinase activity
GO:0007267 IEA cell-cell signaling
GO:0008284 IDA positive regulation of cell proliferation
GO:0009887 IEA organ morphogenesis
GO:0009954 IEA proximal/distal pattern formation
GO:0009986 IEA cell surface
GO:0010717 IMP regulation of epithelial to mesenchymal transition
GO:0016015 ISS morphogen activity
GO:0030199 IMP collagen fibril organization
GO:0030297 ISS transmembrane receptor protein tyrosine kinase activator activity
GO:0030308 IEA negative regulation of cell growth
GO:0030326 IEA embryonic limb morphogenesis
GO:0030502 IMP negative regulation of bone mineralization
GO:0030514 IDA negative regulation of BMP signaling pathway
GO:0033689 IMP negative regulation of osteoblast proliferation
GO:0036122 ISS BMP binding
GO:0042346 IEA positive regulation of NF-kappaB import into nucleus
GO:0043184 ISS vascular endothelial growth factor receptor 2 binding
GO:0043542 IEA endothelial cell migration
GO:0045766 IEA positive regulation of angiogenesis
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046851 IMP negative regulation of bone remodeling
GO:0048018 ISS receptor agonist activity
GO:0048263 IMP determination of dorsal identity
GO:0051092 IEA positive regulation of NF-kappaB transcription factor activity
GO:0051893 IEA regulation of focal adhesion assembly
GO:0051973 IDA positive regulation of telomerase activity
GO:0060394 IDA negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060676 IEA ureteric bud formation
GO:0061098 IEA positive regulation of protein tyrosine kinase activity
GO:0090027 ISS negative regulation of monocyte chemotaxis
GO:0090090 IDA negative regulation of canonical Wnt signaling pathway
GO:0090190 IEA positive regulation of branching involved in ureteric bud morphogenesis
GO:0090191 IEA negative regulation of branching involved in ureteric bud morphogenesis
GO:0090291 IMP negative regulation of osteoclast proliferation
GO:1900086 ISS positive regulation of peptidyl-tyrosine autophosphorylation
GO:1900155 IMP negative regulation of bone trabecula formation
GO:1900158 IMP negative regulation of bone mineralization involved in bone maturation
GO:2000273 ISS positive regulation of receptor activity
GO:2000727 ISS positive regulation of cardiac muscle cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000029546 grem1a gremlin 1 homolog a, cysteine knot superfamily (Xenopus laevis) protein_coding Danio_rerio
ENSDARG00000070612 GREM1 (2 of 3) gremlin 1, DAN family BMP antagonist protein_coding Danio_rerio
ENSDARG00000090720 grem1a gremlin 1 homolog a, cysteine knot superfamily (Xenopus laevis) protein_coding Danio_rerio
ENSMUSG00000074934 Grem1 gremlin 1 protein_coding Mus_musculus

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