C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NK3 homeobox 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000167034 NKX3-1 9606 - 8:23678693-23682927 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000380871 NKX3-1-001 23678693-23682927 protein_coding
  ENST00000523261 NKX3-1-004 23680988-23682889 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000380871ENST00000523261
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000380871 0.304±0.00 0.725±0.00 0.043±0.00 0.433±0.33 0.538±0.24 1.162±0.00 0.623±0.53 0.027±0.00 0.593±0.17 2.312±0.00 1.122±1.02 0.838±1.09 0.317±0.00 8.381±3.75
ENST00000523261 0.446±0.00 N/A N/A N/A 0.326±0.00 N/A N/A N/A N/A N/A 2.074±0.00 0.101±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008FQ CIL_0008FQ_0001 VISTA 8:23193785-23795287
CIL_0007YD CIL_0007YD_0001 VISTA 8:23207989-23809472

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000976 IDA transcription regulatory region sequence-specific DNA binding
GO:0000983 IEA RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0001047 IDA core promoter binding
GO:0001655 IEA urogenital system development
GO:0001656 IEA metanephros development
GO:0001756 IEA somitogenesis
GO:0001934 IDA positive regulation of protein phosphorylation
GO:0003677 IEA DNA binding
GO:0003700 NAS sequence-specific DNA binding transcription factor activity
GO:0004882 IDA androgen receptor activity
GO:0005515 IPI protein binding
GO:0005622 IDA intracellular
GO:0005634 NAS nucleus
GO:0006355 NAS regulation of transcription, DNA-templated
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006919 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007275 TAS multicellular organismal development
GO:0007431 ISS salivary gland development
GO:0007507 IEA heart development
GO:0008134 IPI transcription factor binding
GO:0008284 IMP positive regulation of cell proliferation
GO:0008285 IDA negative regulation of cell proliferation
GO:0008584 IEA male gonad development
GO:0008656 IDA cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0010628 IDA positive regulation of gene expression
GO:0010629 IDA negative regulation of gene expression
GO:0010942 IDA positive regulation of cell death
GO:0014068 IDA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030284 IDA estrogen receptor activity
GO:0030295 IDA protein kinase activator activity
GO:0030331 IDA estrogen receptor binding
GO:0030521 IDA androgen receptor signaling pathway
GO:0030850 IEA prostate gland development
GO:0033574 ISS response to testosterone
GO:0035690 IEP cellular response to drug
GO:0035907 IEA dorsal aorta development
GO:0042826 IPI histone deacetylase binding
GO:0043280 IDA positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043401 IDA steroid hormone mediated signaling pathway
GO:0043491 IMP protein kinase B signaling
GO:0043565 IDA sequence-specific DNA binding
GO:0043569 ISS negative regulation of insulin-like growth factor receptor signaling pathway
GO:0043621 IDA protein self-association
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045860 IDA positive regulation of protein kinase activity
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045930 IDA negative regulation of mitotic cell cycle
GO:0045931 IMP positive regulation of mitotic cell cycle
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048754 ISS branching morphogenesis of an epithelial tube
GO:0050680 ISS negative regulation of epithelial cell proliferation
GO:0051781 IMP positive regulation of cell division
GO:0060037 IEA pharyngeal system development
GO:0060442 ISS branching involved in prostate gland morphogenesis
GO:0060664 ISS epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060770 ISS negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0071347 IEP cellular response to interleukin-1
GO:0071356 IEP cellular response to tumor necrosis factor
GO:0071383 IDA cellular response to steroid hormone stimulus
GO:0071456 IDA cellular response to hypoxia
GO:0071850 IDA mitotic cell cycle arrest
GO:0071899 IDA negative regulation of estrogen receptor binding
GO:0097162 IEA MADS box domain binding
GO:2000836 IDA positive regulation of androgen secretion
GO:2001022 IDA positive regulation of response to DNA damage stimulus
GO:2001235 IDA positive regulation of apoptotic signaling pathway
GO:2001244 IDA positive regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000078280 nkx3-1 NK3 homeobox 1 protein_coding Danio_rerio
ENSMUSG00000022061 Nkx3-1 NK-3 transcription factor, locus 1 (Drosophila) protein_coding Mus_musculus

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