C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NK-3 transcription factor, locus 1 (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022061 Nkx3-1 10090 + 14:69190638-69194662 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000022646 Nkx3-1-001 69190638-69194662 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainColonKidneyLungOvaryPlacentaTestisENSMUST00000022646
Transcript ID Adipose Adrenal Bladder Brain Colon Kidney Lung Ovary Placenta Testis
ENSMUST00000022646 0.011±0.00 0.238±0.09 0.007±0.00 0.076±0.06 0.024±0.00 0.581±0.23 0.013±0.00 0.043±0.04 0.044±0.03 0.446±0.16

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005R4 CIL_0005R4_0002 CGP 14:69171802-69194662
CIL_000460 CIL_000460_0002 CGP 14:69190638-69285112

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000976 ISS transcription regulatory region sequence-specific DNA binding
GO:0000983 IMP RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0001047 ISS core promoter binding
GO:0001655 IEP urogenital system development
GO:0001656 IEP metanephros development
GO:0001756 IEP somitogenesis
GO:0001934 ISS positive regulation of protein phosphorylation
GO:0003677 IDA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0004882 ISS androgen receptor activity
GO:0005515 IPI protein binding
GO:0005622 IDA intracellular
GO:0005634 IDA nucleus
GO:0006366 IMP transcription from RNA polymerase II promoter
GO:0006919 ISS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007431 IMP salivary gland development
GO:0007507 IEP heart development
GO:0008134 IDA transcription factor binding
GO:0008284 ISS positive regulation of cell proliferation
GO:0008285 IGI negative regulation of cell proliferation
GO:0008584 IEP male gonad development
GO:0008656 IEA cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0010628 ISS positive regulation of gene expression
GO:0010629 IEA negative regulation of gene expression
GO:0010942 ISS positive regulation of cell death
GO:0014068 ISS positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030284 ISS estrogen receptor activity
GO:0030295 ISS protein kinase activator activity
GO:0030331 ISS estrogen receptor binding
GO:0030521 ISS androgen receptor signaling pathway
GO:0030850 IEP prostate gland development
GO:0033574 IMP response to testosterone
GO:0035260 TAS internal genitalia morphogenesis
GO:0035690 IEA cellular response to drug
GO:0035907 IEP dorsal aorta development
GO:0042826 IEA histone deacetylase binding
GO:0043280 ISS positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043491 IMP protein kinase B signaling
GO:0043565 IDA sequence-specific DNA binding
GO:0043569 IDA negative regulation of insulin-like growth factor receptor signaling pathway
GO:0043621 ISS protein self-association
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045860 IEA positive regulation of protein kinase activity
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045930 IEA negative regulation of mitotic cell cycle
GO:0045931 ISS positive regulation of mitotic cell cycle
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0048754 IMP branching morphogenesis of an epithelial tube
GO:0050680 IMP negative regulation of epithelial cell proliferation
GO:0051781 ISS positive regulation of cell division
GO:0060037 IEP pharyngeal system development
GO:0060442 IMP branching involved in prostate gland morphogenesis
GO:0060664 IMP epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060770 IMP negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0071347 IEA cellular response to interleukin-1
GO:0071356 IEA cellular response to tumor necrosis factor
GO:0071383 ISS cellular response to steroid hormone stimulus
GO:0071456 IEA cellular response to hypoxia
GO:0071850 IEA mitotic cell cycle arrest
GO:0071899 ISS negative regulation of estrogen receptor binding
GO:0097162 IDA MADS box domain binding
GO:2000836 ISS positive regulation of androgen secretion
GO:2001022 ISS positive regulation of response to DNA damage stimulus
GO:2001235 IEA positive regulation of apoptotic signaling pathway
GO:2001244 ISS positive regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000078280 nkx3-1 NK3 homeobox 1 protein_coding Danio_rerio
ENSG00000167034 NKX3-1 NK3 homeobox 1 protein_coding Homo_sapiens

Loading