C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: prohibitin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000167085 PHB 9606 - 17:49404049-49414905 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000300408 PHB-001 49404052-49414880 protein_coding
  ENST00000393345 PHB-004 49408756-49414858 retained_intron
  ENST00000419140 PHB-002 49405073-49414884 protein_coding
  ENST00000434917 PHB-007 49409350-49414876 protein_coding
  ENST00000446735 PHB-003 49406761-49414848 protein_coding
  ENST00000504124 PHB-009 49405161-49414858 protein_coding
  ENST00000506273 PHB-015 49409076-49414877 processed_transcript
  ENST00000507748 PHB-014 49409449-49412234 retained_intron
  ENST00000508009 PHB-013 49405187-49413253 processed_transcript
  ENST00000511832 PHB-201 49404049-49414905 protein_coding
  ENST00000511933 PHB-016 49405068-49407473 retained_intron
  ENST00000512041 PHB-010 49406759-49414802 protein_coding
  ENST00000513412 PHB-011 49412686-49414878 retained_intron
  ENST00000614445 PHB-202 49404049-49414905 protein_coding
  ENST00000617874 PHB-203 49404049-49414858 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000300408ENST00000393345ENST00000419140ENST00000434917ENST00000504124ENST00000506273ENST00000508009ENST00000511832ENST00000512041
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000300408 N/A N/A 4.283±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 12.080±4.84 9.644±1.39 4.647±0.00
ENST00000393345 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 36.652±0.00 N/A N/A
ENST00000419140 N/A N/A N/A N/A 3.675±0.00 N/A N/A 5.637±0.00 N/A N/A N/A 42.038±15.56 33.075±8.43 7.596±0.00
ENST00000434917 N/A N/A N/A N/A N/A 9.252±0.00 N/A 12.245±0.00 N/A N/A 18.325±0.00 16.705±0.00 N/A N/A
ENST00000504124 24.260±0.00 34.743±0.00 N/A 10.840±0.00 32.889±0.00 34.159±0.00 31.884±0.00 70.710±0.00 39.268±0.00 33.188±0.00 27.159±0.00 32.152±0.00 N/A 21.454±0.00
ENST00000506273 36.874±0.00 42.012±0.00 16.127±0.00 20.064±0.00 48.572±0.00 36.659±0.00 N/A N/A N/A N/A 37.390±0.00 23.666±0.00 N/A 35.700±0.00
ENST00000508009 N/A N/A N/A N/A N/A 15.640±0.00 N/A N/A 12.608±0.00 N/A N/A N/A N/A N/A
ENST00000511832 4.644±0.00 7.670±0.00 N/A 3.869±0.29 4.968±2.63 6.238±1.42 5.226±0.42 10.471±7.16 4.725±1.63 2.852±0.53 5.842±1.10 5.800±0.00 N/A 6.695±0.00
ENST00000512041 N/A N/A 7.940±0.00 12.292±2.84 9.188±0.00 9.725±0.00 11.797±1.57 12.668±0.00 9.200±0.00 11.384±0.00 15.102±0.00 23.603±7.52 37.359±5.40 N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000981 IEA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001649 IDA osteoblast differentiation
GO:0005515 IPI protein binding
GO:0005634 TAS nucleus
GO:0005654 IDA nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005743 TAS mitochondrial inner membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007165 TAS signal transduction
GO:0008285 IMP negative regulation of cell proliferation
GO:0010944 IDA negative regulation of transcription by competitive promoter binding
GO:0016020 IDA membrane
GO:0016575 IDA histone deacetylation
GO:0019899 IPI enzyme binding
GO:0030308 IMP negative regulation of cell growth
GO:0042826 IPI histone deacetylase binding
GO:0042981 TAS regulation of apoptotic process
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0050847 IDA progesterone receptor signaling pathway
GO:0060766 IDA negative regulation of androgen receptor signaling pathway
GO:0070062 IDA extracellular vesicular exosome
GO:0071354 IDA cellular response to interleukin-6
GO:0071897 IEA DNA biosynthetic process
GO:2000323 IDA negative regulation of glucocorticoid receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000057414 phb prohibitin protein_coding Danio_rerio
ENSMUSG00000038845 Phb prohibitin protein_coding Mus_musculus

Loading