C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: insulin-like growth factor 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000167244 IGF2 9606 - 11:2129112-2149603 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000300632 IGF2-201 2129118-2149603 protein_coding
  ENST00000381389 IGF2-009 2132673-2141016 protein_coding
  ENST00000381392 IGF2-004 2132640-2137287 protein_coding
  ENST00000381395 IGF2-003 2129112-2137290 protein_coding
  ENST00000381406 IGF2-002 2129112-2138974 protein_coding
  ENST00000416167 IGF2-001 2129112-2139389 protein_coding
  ENST00000418738 IGF2-005 2132716-2137305 protein_coding
  ENST00000434045 IGF2-007 2132500-2141238 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000300632ENST00000381395ENST00000381406ENST00000416167
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000300632 N/A N/A N/A N/A N/A N/A 0.148±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000381395 124.739±0.00 19.691±0.00 0.766±0.00 3.926±3.60 1.563±0.00 N/A 22.793±0.00 18.241±0.00 117.735±0.00 10.184±9.37 12.797±10.67 208.692±255.20 1069.690±368.14 150.040±0.00
ENST00000381406 49.792±0.00 7.592±0.00 N/A 3.311±0.00 0.489±0.00 0.613±0.00 0.191±0.00 N/A N/A N/A N/A 133.638±124.72 767.892±61.86 33.168±24.97
ENST00000416167 N/A N/A N/A N/A 24.383±0.00 16.219±0.00 13.546±0.00 5.719±0.00 N/A 3.267±0.00 10.145±0.00 261.742±336.57 745.685±636.12 8.598±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008MR CIL_0008MR_0001 VISTA 11:1663842-2266142
CIL_0007RG CIL_0007RG_0001 VISTA 11:1668349-2271510
CIL_00097V CIL_00097V_0001 VISTA 11:1688064-2293510
CIL_0005N8 CIL_0005N8_0002 CGP 11:1947278-2149603
CIL_0009BT CIL_0009BT_0001 VISTA 11:2074187-2675527

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001501 TAS skeletal system development
GO:0001649 IEA osteoblast differentiation
GO:0001934 ISS positive regulation of protein phosphorylation
GO:0002576 TAS platelet degranulation
GO:0005158 IPI insulin receptor binding
GO:0005159 IEA insulin-like growth factor receptor binding
GO:0005179 IEA hormone activity
GO:0005515 IPI protein binding
GO:0005576 TAS:IEA extracellular region
GO:0005615 IEA extracellular space
GO:0005886 TAS plasma membrane
GO:0006006 IEA glucose metabolic process
GO:0006349 TAS regulation of gene expression by genetic imprinting
GO:0006355 NAS regulation of transcription, DNA-templated
GO:0007275 TAS multicellular organismal development
GO:0007565 IEA female pregnancy
GO:0007596 TAS blood coagulation
GO:0007613 IEA memory
GO:0008083 IDA growth factor activity
GO:0008284 IC positive regulation of cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0009314 IEA response to radiation
GO:0009887 IEA organ morphogenesis
GO:0014070 IEA response to organic cyclic compound
GO:0030168 TAS platelet activation
GO:0030546 ISS receptor activator activity
GO:0031017 IEA exocrine pancreas development
GO:0031093 TAS platelet alpha granule lumen
GO:0031667 IEA response to nutrient levels
GO:0032355 IEA response to estradiol
GO:0035094 IEA response to nicotine
GO:0038028 ISS insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0042060 IEA wound healing
GO:0042104 IDA positive regulation of activated T cell proliferation
GO:0042493 IEA response to drug
GO:0043085 ISS positive regulation of catalytic activity
GO:0043410 IDA positive regulation of MAPK cascade
GO:0043539 ISS protein serine/threonine kinase activator activity
GO:0044267 TAS cellular protein metabolic process
GO:0045471 IEA response to ethanol
GO:0045725 ISS positive regulation of glycogen biosynthetic process
GO:0045840 IDA positive regulation of mitosis
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046628 IDA positive regulation of insulin receptor signaling pathway
GO:0050731 ISS positive regulation of peptidyl-tyrosine phosphorylation
GO:0051146 IEA striated muscle cell differentiation
GO:0051781 IEA positive regulation of cell division
GO:0051897 IDA positive regulation of protein kinase B signaling
GO:0070062 IDA extracellular vesicular exosome
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071902 IEA positive regulation of protein serine/threonine kinase activity
GO:0090031 IEA positive regulation of steroid hormone biosynthetic process
GO:2000273 IEA positive regulation of receptor activity
GO:2000467 ISS positive regulation of glycogen (starch) synthase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018643 igf2a insulin-like growth factor 2a protein_coding Danio_rerio
ENSDARG00000033307 igf2b insulin-like growth factor 2b protein_coding Danio_rerio
ENSMUSG00000048583 Igf2 insulin-like growth factor 2 protein_coding Mus_musculus

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