C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: AXL receptor tyrosine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000167601 AXL 9606 + 19:41219203-41261766 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000301178 AXL-001 41219203-41261766 protein_coding
  ENST00000359092 AXL-002 41219235-41260294 protein_coding
  ENST00000593513 AXL-004 41226755-41260204 protein_coding
  ENST00000594880 AXL-005 41220400-41221996 processed_transcript
  ENST00000599659 AXL-003 41219379-41243864 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000301178ENST00000359092ENST00000593513
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000301178 37.281±0.00 9.241±0.00 N/A 6.176±0.00 9.505±6.55 20.898±0.00 3.677±0.00 5.714±0.00 N/A 11.735±0.00 2.687±2.28 6.284±2.94 12.972±2.26 11.423±4.66
ENST00000359092 N/A 2.892±0.00 N/A N/A 1.742±0.00 9.405±0.00 0.556±0.00 1.451±0.00 N/A 5.448±0.00 1.985±0.00 8.974±0.00 4.377±0.00 N/A
ENST00000593513 27.023±0.00 4.741±0.00 0.635±0.00 5.636±2.42 6.543±1.93 9.755±6.84 1.981±0.06 3.840±0.00 9.547±0.00 9.202±7.42 3.336±0.00 4.943±3.02 25.186±0.00 11.071±2.21

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008TR CIL_0008TR_0001 VISTA 19:41131081-41732986

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001764 IEA neuron migration
GO:0001779 IEA natural killer cell differentiation
GO:0001786 IDA phosphatidylserine binding
GO:0001961 IDA positive regulation of cytokine-mediated signaling pathway
GO:0001974 IEA blood vessel remodeling
GO:0004672 IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004714 IEA transmembrane receptor protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005615 IDA extracellular space
GO:0005887 TAS integral component of plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0006909 IDA phagocytosis
GO:0006954 IEA inflammatory response
GO:0007165 TAS signal transduction
GO:0007167 IEA enzyme linked receptor protein signaling pathway
GO:0007283 IEA spermatogenesis
GO:0009986 IDA cell surface
GO:0016021 IEA integral component of membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0021885 IEA forebrain cell migration
GO:0030154 IEA cell differentiation
GO:0030168 IEA platelet activation
GO:0031100 IEA organ regeneration
GO:0031668 IEA cellular response to extracellular stimulus
GO:0032036 IEA myosin heavy chain binding
GO:0032689 IDA negative regulation of interferon-gamma production
GO:0032720 IEA negative regulation of tumor necrosis factor production
GO:0032825 IDA positive regulation of natural killer cell differentiation
GO:0032940 IEA secretion by cell
GO:0034101 IEA erythrocyte homeostasis
GO:0034446 IEA substrate adhesion-dependent cell spreading
GO:0035457 IDA cellular response to interferon-alpha
GO:0042698 IEA ovulation cycle
GO:0043066 IEA negative regulation of apoptotic process
GO:0043277 IEA apoptotic cell clearance
GO:0043491 IEA protein kinase B signaling
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0043548 IEA phosphatidylinositol 3-kinase binding
GO:0045087 IEA innate immune response
GO:0046982 IEA protein heterodimerization activity
GO:0048469 IEP cell maturation
GO:0051250 IEA negative regulation of lymphocyte activation
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0060068 IEA vagina development
GO:0070062 IDA extracellular vesicular exosome
GO:0070301 IEA cellular response to hydrogen peroxide
GO:0071222 IDA cellular response to lipopolysaccharide
GO:0097028 IEP dendritic cell differentiation
GO:2000669 IDA negative regulation of dendritic cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000063691 CABZ01088927.1 Uncharacterized protein protein_coding Danio_rerio
ENSDARG00000088884 CABZ01088930.1 Uncharacterized protein protein_coding Danio_rerio
ENSMUSG00000002602 Axl AXL receptor tyrosine kinase protein_coding Mus_musculus

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