C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000167711 SERPINF2 9606 + 17:1742836-1755268 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000324015 SERPINF2-201 1742836-1755265 protein_coding
  ENST00000382061 SERPINF2-001 1743026-1755268 protein_coding
  ENST00000450523 SERPINF2-004 1742843-1754642 protein_coding
  ENST00000453066 SERPINF2-002 1742836-1748647 protein_coding
  ENST00000453723 SERPINF2-003 1742869-1754200 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000324015ENST00000382061ENST00000450523ENST00000453066ENST00000453723
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000324015 12.201±0.00 N/A N/A 0.258±0.00 0.725±0.00 N/A 26.924±0.00 544.469±0.00 N/A 1.865±0.15 N/A 6.381±0.00
ENST00000382061 N/A 0.886±0.00 N/A N/A N/A 0.582±0.00 57.926±0.00 149.640±0.00 N/A 0.872±0.00 0.418±0.00 1.417±0.00
ENST00000450523 N/A N/A N/A N/A 0.038±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000453066 N/A 3.967±0.00 N/A 0.241±0.00 N/A N/A 62.176±0.00 N/A N/A N/A N/A N/A
ENST00000453723 N/A N/A 0.065±0.00 N/A N/A N/A N/A N/A 0.141±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00060U CIL_00060U_0002 CGP 17:1742836-1777574

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002020 IPI protease binding
GO:0002034 ISS regulation of blood vessel size by renin-angiotensin
GO:0002576 TAS platelet degranulation
GO:0004866 TAS endopeptidase inhibitor activity
GO:0004867 IBA serine-type endopeptidase inhibitor activity
GO:0005515 IPI protein binding
GO:0005576 NAS extracellular region
GO:0005577 IDA fibrinogen complex
GO:0005615 IBA extracellular space
GO:0006953 IEA acute-phase response
GO:0007596 TAS blood coagulation
GO:0009986 IDA cell surface
GO:0010033 IEA response to organic substance
GO:0010757 IDA negative regulation of plasminogen activation
GO:0010951 IBA negative regulation of endopeptidase activity
GO:0030162 IBA regulation of proteolysis
GO:0030168 TAS platelet activation
GO:0030199 ISS collagen fibril organization
GO:0031093 TAS platelet alpha granule lumen
GO:0032967 IDA positive regulation of collagen biosynthetic process
GO:0042730 TAS fibrinolysis
GO:0042803 IPI protein homodimerization activity
GO:0045597 IDA positive regulation of cell differentiation
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046330 IDA positive regulation of JNK cascade
GO:0048514 ISS blood vessel morphogenesis
GO:0048661 ISS positive regulation of smooth muscle cell proliferation
GO:0051496 IDA positive regulation of stress fiber assembly
GO:0051918 IDA negative regulation of fibrinolysis
GO:0070062 IDA extracellular vesicular exosome
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0071636 IDA positive regulation of transforming growth factor beta production
GO:0072562 IDA blood microparticle
GO:2000049 TAS positive regulation of cell-cell adhesion mediated by cadherin

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061383 serpinf2b serine (or cysteine) peptidase inhibitor, clade F, member 2b protein_coding Danio_rerio
ENSDARG00000076448 serpinf2a serine (or cysteine) peptidase inhibitor, clade F, member 2a protein_coding Danio_rerio
ENSMUSG00000038224 Serpinf2 serine (or cysteine) peptidase inhibitor, clade F, member 2 protein_coding Mus_musculus

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