C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: serine (or cysteine) peptidase inhibitor, clade F, member 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000038224 Serpinf2 10090 - 11:75431732-75439591 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000043696 Serpinf2-201 75431736-75439501 protein_coding
  ENSMUST00000108437 Serpinf2-001 75431732-75438900 protein_coding
  ENSMUST00000128330 Serpinf2-002 75435914-75439591 protein_coding
  ENSMUST00000142094 Serpinf2-003 75436433-75439578 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000043696ENSMUST00000108437ENSMUST00000128330ENSMUST00000142094
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000043696 0.123±0.05 0.249±0.20 0.018±0.01 N/A 1.515±0.23 0.650±0.27 N/A 35.557±3.10 442.986±108.61 0.379±0.00 0.016±0.00 0.470±0.38 24.329±29.97 0.159±0.04
ENSMUST00000108437 0.150±0.13 0.038±0.03 0.030±0.00 0.071±0.01 0.084±0.02 0.208±0.07 0.116±0.05 N/A N/A 0.092±0.04 0.016±0.00 0.472±0.32 4.151±3.89 0.064±0.00
ENSMUST00000128330 0.090±0.05 0.316±0.21 N/A 0.128±0.00 0.407±0.29 0.447±0.36 N/A 19.090±3.52 237.638±37.48 N/A 0.056±0.00 0.282±0.16 31.118±1.01 N/A
ENSMUST00000142094 N/A N/A 0.029±0.00 N/A N/A 0.354±0.00 N/A N/A N/A N/A N/A 0.282±0.23 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00039V CIL_00039V_0002 CGP 11:75431732-75454717

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002020 IEA protease binding
GO:0002034 IMP regulation of blood vessel size by renin-angiotensin
GO:0004867 IBA serine-type endopeptidase inhibitor activity
GO:0005515 IEA protein binding
GO:0005577 IEA fibrinogen complex
GO:0005615 IBA extracellular space
GO:0006953 IEA acute-phase response
GO:0009986 IEA cell surface
GO:0010033 IEA response to organic substance
GO:0010757 IEA negative regulation of plasminogen activation
GO:0010951 IBA negative regulation of endopeptidase activity
GO:0030162 IBA regulation of proteolysis
GO:0030199 IMP collagen fibril organization
GO:0032967 IMP positive regulation of collagen biosynthetic process
GO:0042803 IEA protein homodimerization activity
GO:0045597 IMP positive regulation of cell differentiation
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046330 IEA positive regulation of JNK cascade
GO:0048514 IMP blood vessel morphogenesis
GO:0048661 IMP positive regulation of smooth muscle cell proliferation
GO:0051496 IEA positive regulation of stress fiber assembly
GO:0051918 IEA negative regulation of fibrinolysis
GO:0070062 IEA extracellular vesicular exosome
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0071636 IMP positive regulation of transforming growth factor beta production
GO:0072562 IEA blood microparticle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061383 serpinf2b serine (or cysteine) peptidase inhibitor, clade F, member 2b protein_coding Danio_rerio
ENSDARG00000076448 serpinf2a serine (or cysteine) peptidase inhibitor, clade F, member 2a protein_coding Danio_rerio
ENSG00000167711 SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 protein_coding Homo_sapiens

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