C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mixed lineage kinase domain-like
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000168404 MLKL 9606 - 16:74671855-74700960 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000306247 MLKL-002 74671855-74700790 protein_coding
  ENST00000308807 MLKL-001 74671861-74700914 protein_coding
  ENST00000570846 MLKL-003 74671857-74678413 retained_intron
  ENST00000571303 MLKL-007 74675618-74691469 nonsense_mediated_decay
  ENST00000573267 MLKL-005 74691365-74700960 protein_coding
  ENST00000575686 MLKL-006 74695512-74700809 protein_coding
  ENST00000575695 MLKL-004 74671857-74677051 retained_intron
  ENST00000576529 MLKL-008 74672353-74678948 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000306247ENST00000308807ENST00000570846ENST00000573267ENST00000575695ENST00000576529
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000306247 1.205±0.00 2.229±0.00 N/A 0.437±0.00 N/A N/A N/A 1.222±0.00 N/A 3.689±0.00 N/A 1.038±0.49 0.868±0.00 N/A
ENST00000308807 1.026±0.00 2.092±0.00 0.233±0.00 0.057±0.00 2.311±0.33 1.794±1.36 0.433±0.23 1.201±1.09 0.552±0.19 2.035±0.48 N/A 2.746±1.78 2.625±0.49 0.533±0.00
ENST00000570846 0.403±0.00 N/A N/A N/A 0.525±0.09 N/A 0.276±0.00 N/A 0.162±0.00 N/A N/A 0.391±0.00 N/A N/A
ENST00000573267 N/A N/A 0.829±0.00 N/A N/A N/A N/A 0.364±0.00 0.787±0.00 N/A 0.577±0.00 1.562±0.00 N/A N/A
ENST00000575695 N/A N/A N/A N/A N/A N/A N/A 0.476±0.00 N/A N/A N/A N/A N/A 0.157±0.00
ENST00000576529 N/A N/A 2.170±0.00 0.473±0.00 N/A N/A 0.854±0.00 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002PQ CIL_0002PQ_0001 CGP 16:74621394-74700960
CIL_000168 CIL_000168_0001 CGP 16:74671855-74774831

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IDA ATP binding
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019901 IEA protein kinase binding
GO:0032403 IDA protein complex binding
GO:0070207 IDA protein homotrimerization
GO:0070266 IMP necroptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000012519 Mlkl mixed lineage kinase domain-like protein_coding Mus_musculus

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