C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mixed lineage kinase domain-like
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000012519 Mlkl 10090 - 8:111311797-111338177 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000056157 Mlkl-001 111311797-111338177 protein_coding
  ENSMUST00000120432 Mlkl-002 111311800-111338177 protein_coding
  ENSMUST00000135710 Mlkl-003 111311802-111316119 processed_transcript
  ENSMUST00000145862 Mlkl-004 111331817-111337793 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000056157ENSMUST00000120432ENSMUST00000135710ENSMUST00000145862
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000056157 0.417±0.10 N/A N/A N/A 2.262±0.00 1.814±0.00 0.569±0.00 0.248±0.13 0.414±0.17 N/A 0.107±0.00 0.750±0.44 0.167±0.00 1.830±0.00
ENSMUST00000120432 1.878±0.19 3.302±0.52 3.095±0.25 0.087±0.02 1.368±0.28 2.977±0.92 0.599±0.26 0.444±0.13 1.076±0.36 1.426±0.30 0.270±0.12 1.520±1.44 0.992±0.62 2.813±2.31
ENSMUST00000135710 N/A N/A N/A 0.050±0.00 N/A N/A 0.577±0.00 N/A N/A N/A 0.230±0.03 0.465±0.00 N/A N/A
ENSMUST00000145862 N/A N/A N/A N/A N/A 1.518±0.00 N/A 0.418±0.07 1.296±0.06 N/A 0.373±0.05 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002PQ CIL_0002PQ_0002 CGP 8:111270944-111338177
CIL_000168 CIL_000168_0002 CGP 8:111311797-111393824

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IEA protein binding
GO:0005524 IDA ATP binding
GO:0005737 ISS cytoplasm
GO:0005886 ISS plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0019901 IPI protein kinase binding
GO:0032403 IEA protein complex binding
GO:0070207 ISS protein homotrimerization
GO:0070266 IMP necroptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000168404 MLKL mixed lineage kinase domain-like protein_coding Homo_sapiens

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