C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: flap structure-specific endonuclease 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000168496 FEN1 9606 + 11:61792637-61797244 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000305885 FEN1-001 61792637-61797244 protein_coding
  ENST00000535307 FEN1-004 61795940-61797232 protein_coding
  ENST00000535723 FEN1-003 61792951-61795856 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; ColonMuscleOvaryPlacentaTestisENST00000305885ENST00000535307
Transcript ID Colon Muscle Ovary Placenta Testis
ENST00000305885 2.295±0.00 5.588±0.00 7.851±3.26 19.593±1.04 12.037±0.00
ENST00000535307 N/A N/A 20.342±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007WT CIL_0007WT_0001 VISTA 11:61244303-61847279

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000278 TAS mitotic cell cycle
GO:0000287 IEA magnesium ion binding
GO:0000722 TAS telomere maintenance via recombination
GO:0000723 TAS telomere maintenance
GO:0000737 IEA DNA catabolic process, endonucleolytic
GO:0000738 TAS DNA catabolic process, exonucleolytic
GO:0003677 IMP:IEA DNA binding
GO:0003684 TAS damaged DNA binding
GO:0003690 TAS double-stranded DNA binding
GO:0003824 IEA catalytic activity
GO:0004518 IEA nuclease activity
GO:0004519 TAS endonuclease activity
GO:0004523 IDA RNA-DNA hybrid ribonuclease activity
GO:0004527 TAS exonuclease activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005730 IDA nucleolus
GO:0005739 IDA mitochondrion
GO:0006260 TAS DNA replication
GO:0006271 TAS DNA strand elongation involved in DNA replication
GO:0006281 TAS:IEA DNA repair
GO:0006284 TAS base-excision repair
GO:0006302 TAS double-strand break repair
GO:0007613 IEA memory
GO:0008309 TAS double-stranded DNA exodeoxyribonuclease activity
GO:0008409 IDA 5'-3' exonuclease activity
GO:0009650 TAS UV protection
GO:0016020 IDA membrane
GO:0017108 IMP 5'-flap endonuclease activity
GO:0030145 IEA manganese ion binding
GO:0032201 TAS telomere maintenance via semi-conservative replication
GO:0043137 IDA DNA replication, removal of RNA primer
GO:0048256 IEA flap endonuclease activity
GO:0090502 IDA RNA phosphodiester bond hydrolysis, endonucleolytic

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011404 fen1 flap structure-specific endonuclease 1 protein_coding Danio_rerio
ENSMUSG00000024742 Fen1 flap structure specific endonuclease 1 protein_coding Mus_musculus

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