C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: inositol polyphosphate-5-phosphatase, 145kDa
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000168918 INPP5D 9606 + 2:233059967-233207903 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000359570 INPP5D-001 233059967-233207903 protein_coding
  ENST00000415617 INPP5D-015 233161724-233207903 protein_coding
  ENST00000417661 INPP5D-013 233195437-233206952 protein_coding
  ENST00000445964 INPP5D-006 233060398-233207902 protein_coding
  ENST00000451407 INPP5D-016 233060366-233141608 retained_intron
  ENST00000465281 INPP5D-010 233170374-233184483 retained_intron
  ENST00000467393 INPP5D-003 233076262-233125805 processed_transcript
  ENST00000472517 INPP5D-007 233164301-233170576 processed_transcript
  ENST00000474278 INPP5D-004 233120602-233130648 processed_transcript
  ENST00000480983 INPP5D-009 233170021-233171249 retained_intron
  ENST00000491070 INPP5D-014 233204642-233205652 nonsense_mediated_decay
  ENST00000493078 INPP5D-012 233161789-233169329 retained_intron
  ENST00000493632 INPP5D-008 233169560-233182482 retained_intron
  ENST00000496402 INPP5D-011 233122216-233130859 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000359570ENST00000415617ENST00000445964ENST00000451407ENST00000474278ENST00000480983ENST00000493632
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000359570 0.933±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.625±0.00 N/A
ENST00000415617 2.583±0.00 26.926±0.00 N/A 1.104±0.00 1.650±0.00 1.600±0.00 0.401±0.00 2.069±0.00 1.058±0.00 6.155±0.00 0.429±0.23 2.635±0.66 4.362±2.19 1.493±0.48
ENST00000445964 3.895±0.00 20.642±0.00 N/A 1.488±0.17 1.854±0.16 1.533±0.47 0.433±0.23 0.961±0.00 0.874±0.51 4.223±0.28 0.540±0.00 2.925±2.35 5.171±1.12 0.837±0.37
ENST00000451407 N/A N/A N/A N/A 1.707±0.00 N/A N/A N/A 1.008±0.00 N/A N/A N/A N/A N/A
ENST00000474278 N/A N/A 3.240±0.00 N/A N/A 6.530±0.00 N/A N/A N/A 15.502±0.00 N/A 8.206±0.00 N/A N/A
ENST00000480983 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.360±0.00 N/A N/A N/A
ENST00000493632 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.612±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003HY CIL_0003HY_0001 CGP 2:233032672-233207903
CIL_0003HZ CIL_0003HZ_0001 CGP 2:233059967-233295674

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004445 IEA inositol-polyphosphate 5-phosphatase activity
GO:0005515 IPI protein binding
GO:0005829 TAS cytosol
GO:0006644 TAS phospholipid metabolic process
GO:0006661 TAS phosphatidylinositol biosynthetic process
GO:0006796 TAS phosphate-containing compound metabolic process
GO:0006915 IEA apoptotic process
GO:0007165 TAS signal transduction
GO:0007596 TAS blood coagulation
GO:0008285 IEA negative regulation of cell proliferation
GO:0008340 IEA determination of adult lifespan
GO:0009968 IEA negative regulation of signal transduction
GO:0016020 IEA membrane
GO:0016064 IEA immunoglobulin mediated immune response
GO:0016311 IEA dephosphorylation
GO:0017124 IEA SH3 domain binding
GO:0030853 IEA negative regulation of granulocyte differentiation
GO:0030889 IEA negative regulation of B cell proliferation
GO:0034594 IEA phosphatidylinositol trisphosphate phosphatase activity
GO:0035556 IEA intracellular signal transduction
GO:0043065 IEA positive regulation of apoptotic process
GO:0043647 TAS inositol phosphate metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045409 IEA negative regulation of interleukin-6 biosynthetic process
GO:0045579 IEA positive regulation of B cell differentiation
GO:0045621 IEA positive regulation of lymphocyte differentiation
GO:0045648 IEA positive regulation of erythrocyte differentiation
GO:0045656 IEA negative regulation of monocyte differentiation
GO:0045659 IEA negative regulation of neutrophil differentiation
GO:0045671 IEA negative regulation of osteoclast differentiation
GO:0045779 IEA negative regulation of bone resorption
GO:0046856 IEA phosphatidylinositol dephosphorylation
GO:0050777 IEA negative regulation of immune response
GO:0050852 TAS T cell receptor signaling pathway
GO:0050869 IEA negative regulation of B cell activation
GO:0050900 TAS leukocyte migration
GO:0051425 IEA PTB domain binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074283 inpp5d inositol polyphosphate-5-phosphatase D protein_coding Danio_rerio
ENSMUSG00000026288 Inpp5d inositol polyphosphate-5-phosphatase D protein_coding Mus_musculus

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