C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: inositol polyphosphate-5-phosphatase D
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026288 Inpp5d 10090 + 1:87620312-87720507 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000042275 Inpp5d-002 87620362-87720503 protein_coding
  ENSMUST00000072999 Inpp5d-004 87620398-87720503 nonsense_mediated_decay
  ENSMUST00000163222 Inpp5d-008 87620356-87635379 retained_intron
  ENSMUST00000163548 Inpp5d-011 87709341-87712159 processed_transcript
  ENSMUST00000163576 Inpp5d-010 87621674-87667916 protein_coding
  ENSMUST00000164592 Inpp5d-007 87620389-87645154 processed_transcript
  ENSMUST00000165554 Inpp5d-009 87620627-87667992 protein_coding
  ENSMUST00000167032 Inpp5d-005 87676239-87720502 protein_coding
  ENSMUST00000168783 Inpp5d-003 87620399-87719694 protein_coding
  ENSMUST00000169754 Inpp5d-001 87620312-87720507 protein_coding
  ENSMUST00000170300 Inpp5d-006 87676239-87720502 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000042275ENSMUST00000072999ENSMUST00000163222ENSMUST00000167032ENSMUST00000168783ENSMUST00000169754ENSMUST00000170300
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000042275 1.671±0.78 1.524±0.79 0.537±0.10 0.197±0.03 4.791±1.59 1.226±0.02 0.274±0.00 0.625±0.17 0.791±0.48 3.032±1.83 0.213±0.14 1.345±0.79 0.246±0.03 1.188±0.00
ENSMUST00000072999 N/A N/A N/A N/A N/A N/A 0.979±0.00 N/A 0.168±0.00 N/A 0.222±0.00 N/A N/A N/A
ENSMUST00000163222 N/A 11.631±1.87 N/A N/A 53.199±3.02 11.381±3.00 N/A N/A 1.733±0.00 45.906±0.00 N/A 12.023±0.61 N/A N/A
ENSMUST00000167032 1.107±0.00 N/A 0.627±0.25 0.223±0.00 2.392±0.00 0.652±0.00 0.190±0.00 N/A 2.179±0.77 N/A 0.279±0.32 0.767±0.14 0.472±0.35 N/A
ENSMUST00000168783 1.096±0.00 1.399±0.32 N/A 0.416±0.07 3.458±0.83 1.015±0.31 0.423±0.06 0.912±0.15 1.346±0.61 3.465±0.77 0.124±0.06 1.039±0.50 0.440±0.25 1.241±0.40
ENSMUST00000169754 3.379±1.13 1.774±0.94 1.080±0.02 0.370±0.00 6.024±2.02 1.772±0.62 0.843±0.69 1.348±0.32 1.601±1.04 7.849±1.85 0.264±0.09 1.539±0.65 0.347±0.12 0.857±0.27
ENSMUST00000170300 1.177±0.00 N/A 0.538±0.12 0.303±0.14 3.916±0.00 N/A 0.203±0.00 0.712±0.00 1.477±0.19 N/A 0.199±0.01 1.166±0.48 0.290±0.12 0.584±0.05

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003HY CIL_0003HY_0002 CGP 1:87509889-87720507
CIL_0003HZ CIL_0003HZ_0002 CGP 1:87620312-87792428

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004445 IDA inositol-polyphosphate 5-phosphatase activity
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0005886 IEA plasma membrane
GO:0006915 IEA apoptotic process
GO:0008285 IDA negative regulation of cell proliferation
GO:0008340 IMP determination of adult lifespan
GO:0009968 IMP negative regulation of signal transduction
GO:0016064 IMP immunoglobulin mediated immune response
GO:0016311 IDA dephosphorylation
GO:0017124 IDA SH3 domain binding
GO:0030853 IMP negative regulation of granulocyte differentiation
GO:0030889 IMP negative regulation of B cell proliferation
GO:0034594 IDA phosphatidylinositol trisphosphate phosphatase activity
GO:0035556 IMP intracellular signal transduction
GO:0043065 IMP positive regulation of apoptotic process
GO:0045409 IMP negative regulation of interleukin-6 biosynthetic process
GO:0045579 IMP positive regulation of B cell differentiation
GO:0045621 IMP positive regulation of lymphocyte differentiation
GO:0045648 IMP positive regulation of erythrocyte differentiation
GO:0045656 IMP negative regulation of monocyte differentiation
GO:0045659 IMP negative regulation of neutrophil differentiation
GO:0045671 IMP negative regulation of osteoclast differentiation
GO:0045779 IMP negative regulation of bone resorption
GO:0046856 IEA phosphatidylinositol dephosphorylation
GO:0050777 IMP negative regulation of immune response
GO:0050869 IMP negative regulation of B cell activation
GO:0051425 IDA PTB domain binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074283 inpp5d inositol polyphosphate-5-phosphatase D protein_coding Danio_rerio
ENSG00000168918 INPP5D inositol polyphosphate-5-phosphatase, 145kDa protein_coding Homo_sapiens

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