C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: CASP2 and RIPK1 domain containing adaptor with death domain
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000169372 CRADD 9606 + 12:93677375-93894840 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000332896 CRADD-001 93677375-93850736 protein_coding
  ENST00000542893 CRADD-002 93677717-93850756 protein_coding
  ENST00000547383 CRADD-006 93733559-93738636 processed_transcript
  ENST00000548330 CRADD-009 93848660-93850756 processed_transcript
  ENST00000548483 CRADD-003 93677399-93894727 protein_coding
  ENST00000549615 CRADD-008 93677375-93846527 processed_transcript
  ENST00000550030 CRADD-010 93826719-93850695 processed_transcript
  ENST00000550766 CRADD-012 93815136-93816109 processed_transcript
  ENST00000551065 CRADD-004 93677399-93894840 nonsense_mediated_decay
  ENST00000552033 CRADD-005 93677377-93738625 protein_coding
  ENST00000552983 CRADD-007 93677375-93738636 protein_coding
  ENST00000609189 CRADD-011 93815408-93850667 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000332896ENST00000547383ENST00000548330ENST00000549615ENST00000550766ENST00000552033ENST00000552983ENST00000609189
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000332896 3.938±0.00 2.807±0.00 0.949±0.00 2.640±0.08 4.705±0.00 4.600±0.00 7.607±5.39 6.386±1.11 6.158±4.18 2.989±2.28 3.875±1.17 3.907±2.80 4.200±2.07 4.490±2.17
ENST00000547383 N/A N/A 2.620±0.00 N/A 1.979±0.00 1.595±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000548330 N/A N/A N/A N/A N/A N/A N/A N/A 0.456±0.00 N/A N/A 0.388±0.08 N/A N/A
ENST00000549615 N/A N/A N/A 2.950±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000550766 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.066±0.00
ENST00000552033 N/A 1.678±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000552983 N/A N/A 0.615±0.00 N/A N/A N/A N/A 1.397±0.00 1.284±0.00 N/A N/A 1.959±0.00 N/A 2.831±0.00
ENST00000609189 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.691±0.00 N/A 1.132±0.00 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002020 IPI protease binding
GO:0005515 IPI:IEA protein binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0006919 IEA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006977 IMP DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007165 IEA signal transduction
GO:0008625 IC extrinsic apoptotic signaling pathway via death domain receptors
GO:0030674 IPI protein binding, bridging
GO:0042981 IEA regulation of apoptotic process
GO:0070513 IPI death domain binding
GO:0071260 IEP cellular response to mechanical stimulus
GO:2001235 IEA positive regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000028192 cradd CASP2 and RIPK1 domain containing adaptor with death domain protein_coding Danio_rerio
ENSMUSG00000045867 Cradd CASP2 and RIPK1 domain containing adaptor with death domain protein_coding Mus_musculus

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