C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: natriuretic peptide receptor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000169418 NPR1 9606 + 1:153678637-153693992 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000368677 NPR1-002 153688724-153693968 retained_intron
  ENST00000368680 NPR1-001 153678637-153693992 protein_coding
  ENST00000413826 NPR1-003 153680801-153681792 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000368677ENST00000368680
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000368677 N/A N/A N/A 0.061±0.00 N/A N/A N/A N/A N/A N/A N/A 6.704±0.00 N/A N/A
ENST00000368680 43.457±0.00 13.103±0.00 2.216±0.00 0.404±0.00 30.961±27.21 14.508±12.61 3.511±1.64 19.523±17.94 5.717±1.46 14.098±9.11 1.472±0.00 15.343±18.15 21.749±4.27 4.872±4.66

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000LZ CIL_0000LZ_0002 CGP 1:153678637-153774808

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004383 IDA guanylate cyclase activity
GO:0004672 IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005525 IEA GTP binding
GO:0005886 IEA plasma membrane
GO:0005887 IC integral component of plasma membrane
GO:0006182 IDA cGMP biosynthetic process
GO:0006468 IEA protein phosphorylation
GO:0007166 NAS cell surface receptor signaling pathway
GO:0007168 IDA receptor guanylyl cyclase signaling pathway
GO:0007186 NAS G-protein coupled receptor signaling pathway
GO:0007589 TAS body fluid secretion
GO:0008217 NAS regulation of blood pressure
GO:0008528 NAS G-protein coupled peptide receptor activity
GO:0009190 IEA cyclic nucleotide biosynthetic process
GO:0016525 TAS negative regulation of angiogenesis
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016849 IEA phosphorus-oxygen lyase activity
GO:0016941 IDA natriuretic peptide receptor activity
GO:0017046 IEA peptide hormone binding
GO:0019901 IEA protein kinase binding
GO:0030308 NAS negative regulation of cell growth
GO:0030828 IEA positive regulation of cGMP biosynthetic process
GO:0035556 IEA intracellular signal transduction
GO:0035810 TAS positive regulation of urine volume
GO:0035815 TAS positive regulation of renal sodium excretion
GO:0042312 NAS regulation of vasodilation
GO:0042417 IEA dopamine metabolic process
GO:0042562 IPI hormone binding
GO:0043114 TAS regulation of vascular permeability
GO:0043235 IDA receptor complex
GO:0048662 IEA negative regulation of smooth muscle cell proliferation
GO:0050880 IEA regulation of blood vessel size

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018750 NPR1 (1 of 2) natriuretic peptide receptor 1 protein_coding Danio_rerio
ENSDARG00000031751 npr1a natriuretic peptide receptor 1a protein_coding Danio_rerio
ENSMUSG00000027931 Npr1 natriuretic peptide receptor 1 protein_coding Mus_musculus

Loading