C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: neuroligin 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000169760 NLGN1 9606 + 3:173396284-174286644 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000361589 NLGN1-002 173584555-174283123 protein_coding
  ENST00000401917 NLGN1-201 174275314-174281303 protein_coding
  ENST00000413821 NLGN1-007 173397780-173604629 protein_coding
  ENST00000415045 NLGN1-003 173584920-174278982 protein_coding
  ENST00000423427 NLGN1-005 173396284-173604637 protein_coding
  ENST00000457714 NLGN1-001 173398448-174286644 protein_coding
  ENST00000466350 NLGN1-010 174136435-174279362 processed_transcript
  ENST00000469564 NLGN1-011 174136448-174279092 processed_transcript
  ENST00000469727 NLGN1-006 174136462-174279055 processed_transcript
  ENST00000482120 NLGN1-009 173397782-173399871 processed_transcript
  ENST00000490929 NLGN1-008 174136462-174275513 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000361589ENST00000401917ENST00000413821ENST00000415045ENST00000423427ENST00000457714ENST00000466350
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000361589 N/A 0.110±0.00 N/A 2.760±0.05 0.187±0.07 0.125±0.00 0.834±0.00 0.269±0.00 0.832±0.82 0.021±0.00 0.051±0.00 0.170±0.07 0.155±0.04 0.529±0.11
ENST00000401917 0.328±0.00 N/A 0.403±0.00 4.078±0.00 N/A N/A 0.670±0.00 N/A N/A 0.145±0.06 N/A N/A N/A 1.212±0.00
ENST00000413821 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.505±0.00 N/A N/A N/A
ENST00000415045 N/A N/A N/A N/A 0.718±0.00 0.735±0.00 1.275±0.00 0.034±0.00 N/A N/A N/A 0.278±0.00 N/A N/A
ENST00000423427 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.040±0.00 N/A N/A
ENST00000457714 N/A N/A N/A N/A 0.050±0.00 N/A N/A N/A N/A N/A N/A 0.130±0.00 0.046±0.00 0.136±0.00
ENST00000466350 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.048±0.00 N/A N/A 2.241±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002087 IEA regulation of respiratory gaseous exchange by neurological system process
GO:0004872 ISS receptor activity
GO:0005515 IEA protein binding
GO:0005887 ISS integral component of plasma membrane
GO:0006605 ISS protein targeting
GO:0007157 ISS heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007158 ISS neuron cell-cell adhesion
GO:0007399 ISS nervous system development
GO:0007416 ISS synapse assembly
GO:0008152 IEA metabolic process
GO:0009897 IEA external side of plasma membrane
GO:0009986 ISS cell surface
GO:0016080 ISS synaptic vesicle targeting
GO:0016339 ISS calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0016787 IEA hydrolase activity
GO:0017146 IEA N-methyl-D-aspartate selective glutamate receptor complex
GO:0023041 TAS neuronal signal transduction
GO:0030054 IEA cell junction
GO:0030165 IDA PDZ domain binding
GO:0030425 ISS dendrite
GO:0032230 ISS positive regulation of synaptic transmission, GABAergic
GO:0032433 ISS filopodium tip
GO:0035418 ISS protein localization to synapse
GO:0042043 ISS neurexin family protein binding
GO:0045184 ISS establishment of protein localization
GO:0045202 ISS synapse
GO:0045211 IEA postsynaptic membrane
GO:0045664 ISS regulation of neuron differentiation
GO:0046983 ISS protein dimerization activity
GO:0048789 ISS cytoskeletal matrix organization at active zone
GO:0050804 IEA regulation of synaptic transmission
GO:0050808 IEA synapse organization
GO:0050839 ISS cell adhesion molecule binding
GO:0051260 ISS protein homooligomerization
GO:0051290 IEA protein heterotetramerization
GO:0051491 ISS positive regulation of filopodium assembly
GO:0051965 ISS positive regulation of synapse assembly
GO:0051968 ISS positive regulation of synaptic transmission, glutamatergic
GO:0060999 ISS positive regulation of dendritic spine development
GO:0072553 ISS terminal button organization
GO:0097091 ISS synaptic vesicle clustering
GO:0097104 ISS postsynaptic membrane assembly
GO:0097105 ISS presynaptic membrane assembly
GO:0097113 ISS alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering
GO:0097114 ISS N-methyl-D-aspartate receptor clustering
GO:0097115 ISS neurexin clustering
GO:0097119 ISS postsynaptic density protein 95 clustering
GO:0097120 ISS receptor localization to synapse
GO:0097481 TAS neuronal postsynaptic density
GO:1900029 ISS positive regulation of ruffle assembly
GO:1900244 ISS positive regulation of synaptic vesicle endocytosis
GO:1902533 ISS positive regulation of intracellular signal transduction
GO:2000302 ISS positive regulation of synaptic vesicle exocytosis
GO:2000310 ISS regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000311 ISS regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:2000463 ISS positive regulation of excitatory postsynaptic membrane potential

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000077710 nlgn1 neuroligin 1 protein_coding Danio_rerio
ENSMUSG00000063887 Nlgn1 neuroligin 1 protein_coding Mus_musculus

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