C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: neuroligin 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000063887 Nlgn1 10090 - 3:25431811-26133734 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000075054 Nlgn1-201 25431811-26133734 protein_coding
  ENSMUST00000108308 Nlgn1-202 25431811-26133734 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000075054ENSMUST00000108308
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000075054 N/A N/A N/A 1.972±0.92 N/A N/A N/A N/A 0.002±0.00 0.022±0.00 0.020±0.00 N/A N/A N/A
ENSMUST00000108308 0.070±0.01 0.033±0.00 0.112±0.00 3.582±0.85 0.067±0.04 0.095±0.04 0.023±0.02 0.058±0.02 0.011±0.01 0.083±0.04 0.007±0.00 0.339±0.11 0.019±0.01 0.028±0.02

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002087 IGI regulation of respiratory gaseous exchange by neurological system process
GO:0004872 IBA receptor activity
GO:0005515 IPI protein binding
GO:0005887 IMP integral component of plasma membrane
GO:0007155 IEA cell adhesion
GO:0007157 IDA heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007158 IDA neuron cell-cell adhesion
GO:0007399 IDA nervous system development
GO:0007416 IDA synapse assembly
GO:0009897 IDA external side of plasma membrane
GO:0009986 ISS cell surface
GO:0016080 IMP synaptic vesicle targeting
GO:0016339 ISS calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0030054 IEA cell junction
GO:0030425 ISS dendrite
GO:0032230 ISS positive regulation of synaptic transmission, GABAergic
GO:0032433 ISS filopodium tip
GO:0035418 IDA protein localization to synapse
GO:0042043 IMP neurexin family protein binding
GO:0045184 IMP establishment of protein localization
GO:0045202 ISS synapse
GO:0045211 IEA postsynaptic membrane
GO:0045664 IDA regulation of neuron differentiation
GO:0046983 ISS protein dimerization activity
GO:0048789 IMP cytoskeletal matrix organization at active zone
GO:0050804 IGI regulation of synaptic transmission
GO:0050808 ISO synapse organization
GO:0051260 IDA protein homooligomerization
GO:0051491 ISS positive regulation of filopodium assembly
GO:0051965 ISS positive regulation of synapse assembly
GO:0051968 ISS positive regulation of synaptic transmission, glutamatergic
GO:0060076 IC excitatory synapse
GO:0060999 ISS positive regulation of dendritic spine development
GO:0072553 IMP terminal button organization
GO:0097091 IDA synaptic vesicle clustering
GO:0097104 IDA postsynaptic membrane assembly
GO:0097105 IDA presynaptic membrane assembly
GO:0097113 IDA alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering
GO:0097114 ISS N-methyl-D-aspartate receptor clustering
GO:0097115 IDA neurexin clustering
GO:0097119 IDA postsynaptic density protein 95 clustering
GO:0097120 IDA receptor localization to synapse
GO:1900244 IMP positive regulation of synaptic vesicle endocytosis
GO:2000302 IMP positive regulation of synaptic vesicle exocytosis
GO:2000310 IDA regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000311 ISS regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:2000463 IDA positive regulation of excitatory postsynaptic membrane potential

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000077710 nlgn1 neuroligin 1 protein_coding Danio_rerio
ENSG00000169760 NLGN1 neuroligin 1 protein_coding Homo_sapiens

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